środa, 18 lutego 2015

Fwd: PNAS Table of Contents for 17 February 2015; Vol. 112, No. 7


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PNAS    Proceedings of the National Academy of Sciences
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Mandibular evidence supports Homo floresiensis as a distinct species
Michael Carrington Westaway, Arthur C. Durband, Colin P. Groves, and Mark Collard
Reply to Westaway et al.: Mandibular misrepresentations fail to support the invalid species Homo floresiensis
Robert B. Eckhardt, Maciej Henneberg, Sakdapong Chavanaves, Alexander S. Weller, and Kenneth J. Hsü

Opinion
Opinion: Addressing systemic problems in the biomedical research enterprise Front Matter
Bruce Alberts, Marc W. Kirschner, Shirley Tilghman, and Harold Varmus
Leading scientists discuss current issues.

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Physical Sciences
Applied Physical Sciences
Chemistry
Elucidation of synaptonemal complex organization by super-resolution imaging with isotropic resolution Open Access Article
Katharina Schücker, Thorge Holm, Christian Franke, Markus Sauer, and Ricardo Benavente
Earth, Atmospheric, and Planetary Sciences
Methane emissions from natural gas infrastructure and use in the urban region of Boston, Massachusetts Open Access Article From the Cover
Kathryn McKain, Adrian Down, Steve M. Raciti, John Budney, Lucy R. Hutyra, Cody Floerchinger, Scott C. Herndon, Thomas Nehrkorn, Mark S. Zahniser, Robert B. Jackson, Nathan Phillips, and Steven C. Wofsy
Droplet fragmentation: 3D imaging of a previously unidentified pore-scale process during multiphase flow in porous media
Tannaz Pak, Ian B. Butler, Sebastian Geiger, Marinus I. J. van Dijke, and Ken S. Sorbie
Sulfur-cycling fossil bacteria from the 1.8-Ga Duck Creek Formation provide promising evidence of evolution's null hypothesis
J. William Schopf, Anatoliy B. Kudryavtsev, Malcolm R. Walter, Martin J. Van Kranendonk, Kenneth H. Williford, Reinhard Kozdon, John W. Valley, Victor A. Gallardo, Carola Espinoza, and David T. Flannery
Engineering
Highly multiplexed profiling of single-cell effector functions reveals deep functional heterogeneity in response to pathogenic ligands
Yao Lu, Qiong Xue, Markus R. Eisele, Endah S. Sulistijo, Kara Brower, Lin Han, El-ad David Amir, Dana Pe'er, Kathryn Miller-Jensen, and Rong Fan
Dynamic phototuning of 3D hydrogel stiffness
Ryan S. Stowers, Shane C. Allen, and Laura J. Suggs
Gold–silica quantum rattles for multimodal imaging and therapy
Mathew Hembury, Ciro Chiappini, Sergio Bertazzo, Tammy L. Kalber, Glenna L. Drisko, Olumide Ogunlade, Simon Walker-Samuel, Katla Sai Krishna, Coline Jumeaux, Paul Beard, Challa S. S. R. Kumar, Alexandra E. Porter, Mark F. Lythgoe, Cédric Boissière, Clément Sanchez, and Molly M. Stevens
Physics
Scaling laws describe memories of host–pathogen riposte in the HIV population
John P. Barton, Mehran Kardar, and Arup K. Chakraborty
Magnetic nanopantograph in the SrCu2(BO3)2 Shastry–Sutherland lattice
Guillaume Radtke, Andrés Saúl, Hanna A. Dabkowska, Myron B. Salamon, and Marcelo Jaime
Sustainability Science
Rapid loss of lakes on the Mongolian Plateau
Shengli Tao, Jingyun Fang, Xia Zhao, Shuqing Zhao, Haihua Shen, Huifeng Hu, Zhiyao Tang, Zhiheng Wang, and Qinghua Guo

Social Sciences
Psychological and Cognitive Sciences
Self-affirmation alters the brain's response to health messages and subsequent behavior change
Emily B. Falk, Matthew Brook O'Donnell, Christopher N. Cascio, Francis Tinney, Yoona Kang, Matthew D. Lieberman, Shelley E. Taylor, Lawrence An, Kenneth Resnicow, and Victor J. Strecher
Role of the motor system in language knowledge
Iris Berent, Anna-Katharine Brem, Xu Zhao, Erica Seligson, Hong Pan, Jane Epstein, Emily Stern, Albert M. Galaburda, and Alvaro Pascual-Leone
Social Sciences
Sustainability Science
Methane emissions from natural gas infrastructure and use in the urban region of Boston, Massachusetts Open Access Article From the Cover
Kathryn McKain, Adrian Down, Steve M. Raciti, John Budney, Lucy R. Hutyra, Cody Floerchinger, Scott C. Herndon, Thomas Nehrkorn, Mark S. Zahniser, Robert B. Jackson, Nathan Phillips, and Steven C. Wofsy

Biological Sciences
Applied Biological Sciences
Dynamic phototuning of 3D hydrogel stiffness
Ryan S. Stowers, Shane C. Allen, and Laura J. Suggs
Tunable control of antibody immobilization using electric field
Sam Emaminejad, Mehdi Javanmard, Chaitanya Gupta, Shuai Chang, Ronald W. Davis, and Roger T. Howe
Glycosylation profiles determine extravasation and disease-targeting properties of armed antibodies
Dario Venetz, Christian Hess, Chia-wei Lin, Markus Aebi, and Dario Neri
Biochemistry
Mitochondrial peroxiredoxin functions as crucial chaperone reservoir in Leishmania infantum
Filipa Teixeira, Helena Castro, Tânia Cruz, Eric Tse, Philipp Koldewey, Daniel R. Southworth, Ana M. Tomás, and Ursula Jakob
Distinct activation of an E2 ubiquitin-conjugating enzyme by its cognate E3 ligases
Itamar Cohen, Reuven Wiener, Yuval Reiss, and Tommer Ravid
Archaeal replicative primases can perform translesion DNA synthesis Open Access Article
Stanislaw K. Jozwiakowski, Farimah Borazjani Gholami, and Aidan J. Doherty
A conserved amphipathic helix is required for membrane tubule formation by Yop1p Open Access Article
Jacob P. Brady, Jolyon K. Claridge, Peter G. Smith, and Jason R. Schnell
Structural basis for transcription reactivation by RapA
Bin Liu, Yuhong Zuo, and Thomas A. Steitz
Inhibition of the β-barrel assembly machine by a peptide that binds BamD
Christine L. Hagan, Joseph S. Wzorek, and Daniel Kahne
Distinct pathways of RNA polymerase regulation by a phage-encoded factor
Daria Esyunina, Evgeny Klimuk, Konstantin Severinov, and Andrey Kulbachinskiy
A CaMKII/PDE4D negative feedback regulates cAMP signaling
Delphine Mika, Wito Richter, and Marco Conti
Biophysics and Computational Biology
Scaling laws describe memories of host–pathogen riposte in the HIV population
John P. Barton, Mehran Kardar, and Arup K. Chakraborty
Elucidation of synaptonemal complex organization by super-resolution imaging with isotropic resolution Open Access Article
Katharina Schücker, Thorge Holm, Christian Franke, Markus Sauer, and Ricardo Benavente
Residue-level resolution of alphavirus envelope protein interactions in pH-dependent fusion
Xiancheng Zeng, Suchetana Mukhopadhyay, and Charles L. Brooks III
Proton-coupled electron transfer and the role of water molecules in proton pumping by cytochrome c oxidase
Vivek Sharma, Giray Enkavi, Ilpo Vattulainen, Tomasz Róg, and Mårten Wikström
Single liposome analysis of peptide translocation by the ABC transporter TAPL
Tina Zollmann, Gemma Moiset, Franz Tumulka, Robert Tampé, Bert Poolman, and Rupert Abele
Absence of knots in known RNA structures
Cristian Micheletti, Marco Di Stefano, and Henri Orland
Phylogenomics with paralogs
Marc Hellmuth, Nicolas Wieseke, Marcus Lechner, Hans-Peter Lenhof, Martin Middendorf, and Peter F. Stadler
Molecular mechanisms underlying the effect of the novel BK channel opener GoSlo: Involvement of the S4/S5 linker and the S6 segment
Timothy I. Webb, Aravind Singh Kshatri, Roddy J. Large, Adebola Morayo Akande, Subhrangsu Roy, Gerard P. Sergeant, Noel G. McHale, Keith D. Thornbury, and Mark A. Hollywood
Cell Biology
Autoinhibition and relief mechanism for Polo-like kinase 4
Joseph E. Klebba, Daniel W. Buster, Tiffany A. McLamarrah, Nasser M. Rusan, and Gregory C. Rogers
Aged insulin granules display reduced microtubule-dependent mobility and are disposed within actin-positive multigranular bodies Open Access Article
Peter Hoboth, Andreas Müller, Anna Ivanova, Hassan Mziaut, Jaber Dehghany, Anke Sönmez, Martina Lachnit, Michael Meyer-Hermann, Yannis Kalaidzidis, and Michele Solimena
Genome-wide targeting of the epigenetic regulatory protein CTCF to gene promoters by the transcription factor TFII-I Open Access Article
Rodrigo Peña-Hernández, Maud Marques, Khalid Hilmi, Teijun Zhao, Amine Saad, Moulay A. Alaoui-Jamali, Sonia V. del Rincon, Todd Ashworth, Ananda L. Roy, Beverly M. Emerson, and Michael Witcher
The autophagic machinery ensures nonlytic transmission of mycobacteria
Lilli Gerstenmaier, Rachel Pilla, Lydia Herrmann, Hendrik Herrmann, Monica Prado, Geno J. Villafano, Margot Kolonko, Rudolph Reimer, Thierry Soldati, Jason S. King, and Monica Hagedorn
Developmental Biology
Analysis of gene–environment interactions in postnatal development of the mammalian intestine Inaugural Article
Seth Rakoff-Nahoum, Yong Kong, Steven H. Kleinstein, Sathish Subramanian, Philip P. Ahern, Jeffrey I. Gordon, and Ruslan Medzhitov
Adipogenesis and epicardial adipose tissue: A novel fate of the epicardium induced by mesenchymal transformation and PPARγ activation
Yukiko Yamaguchi, Susana Cavallero, Michaela Patterson, Hua Shen, Jian Xu, S. Ram Kumar, and Henry M. Sucov
Ecology
Environmental Sciences
Breakdown of coral colonial form under reduced pH conditions is initiated in polyps and mediated through apoptosis
Hagit Kvitt, Esti Kramarsky-Winter, Keren Maor-Landaw, Keren Zandbank, Ariel Kushmaro, Hanna Rosenfeld, Maoz Fine, and Dan Tchernov
Evolution
Bacterial proteins pinpoint a single eukaryotic root
Romain Derelle, Guifré Torruella, Vladimír Klimeš, Henner Brinkmann, Eunsoo Kim, Čestmír Vlček, B. Franz Lang, and Marek Eliáš
Sulfur-cycling fossil bacteria from the 1.8-Ga Duck Creek Formation provide promising evidence of evolution's null hypothesis
J. William Schopf, Anatoliy B. Kudryavtsev, Malcolm R. Walter, Martin J. Van Kranendonk, Kenneth H. Williford, Reinhard Kozdon, John W. Valley, Victor A. Gallardo, Carola Espinoza, and David T. Flannery
Rate of language evolution is affected by population size
Lindell Bromham, Xia Hua, Thomas G. Fitzpatrick, and Simon J. Greenhill
Dynamics of gene circuits shapes evolvability Open Access Article
Alba Jiménez, Andreea Munteanu, and James Sharpe
Crossovers are associated with mutation and biased gene conversion at recombination hotspots Open Access Article
Barbara Arbeithuber, Andrea J. Betancourt, Thomas Ebner, and Irene Tiemann-Boege
Matching times of leading and following suggest cooperation through direct reciprocity during V-formation flight in ibis Open Access Article
Bernhard Voelkl, Steven J. Portugal, Markus Unsöld, James R. Usherwood, Alan M. Wilson, and Johannes Fritz
Genetics
NADPH oxidase 4 is a critical mediator in Ataxia telangiectasia disease Open Access Article
Urbain Weyemi, Christophe E. Redon, Towqir Aziz, Rohini Choudhuri, Daisuke Maeda, Palak R. Parekh, Michael Y. Bonner, Jack L. Arbiser, and William M. Bonner
Haploinsufficiency screen highlights two distinct groups of ribosomal protein genes essential for embryonic stem cell fate Open Access Article
Simon Fortier, Tara MacRae, Mélanie Bilodeau, Tobias Sargeant, and Guy Sauvageau
Immunology and Inflammation
PTEN regulates natural killer cell trafficking in vivo
Jeffrey W. Leong, Stephanie E. Schneider, Ryan P. Sullivan, Bijal A. Parikh, Bryan A. Anthony, Anvita Singh, Brea A. Jewell, Timothy Schappe, Julia A. Wagner, Daniel C. Link, Wayne M. Yokoyama, and Todd A. Fehniger
Suppression of systemic autoimmunity by the innate immune adaptor STING
Shruti Sharma, Allison M. Campbell, Jennie Chan, Stefan A. Schattgen, Gregory M. Orlowski, Ribhu Nayar, Annie H. Huyler, Kerstin Nündel, Chandra Mohan, Leslie J. Berg, Mark J. Shlomchik, Ann Marshak-Rothstein, and Katherine A. Fitzgerald
The SWI/SNF chromatin remodeling complex regulates germinal center formation by repressing Blimp-1 expression
Jinwook Choi, Shin Jeon, Seungjin Choi, Kyungsoo Park, and Rho Hyun Seong
Overlapping hotspots in CDRs are critical sites for V region diversification Open Access Article
Lirong Wei, Richard Chahwan, Shanzhi Wang, Xiaohua Wang, Phuong T. Pham, Myron F. Goodman, Aviv Bergman, Matthew D. Scharff, and Thomas MacCarthy
Noninvasive mapping of pancreatic inflammation in recent-onset type-1 diabetes patients
Jason L. Gaglia, Mukesh Harisinghani, Iman Aganj, Gregory R. Wojtkiewicz, Sandeep Hedgire, Christophe Benoist, Diane Mathis, and Ralph Weissleder
Macrophages eat cancer cells using their own calreticulin as a guide: Roles of TLR and Btk Open Access Article
Mingye Feng, James Y. Chen, Rachel Weissman-Tsukamoto, Jens-Peter Volkmer, Po Yi Ho, Kelly M. McKenna, Samuel Cheshier, Michael Zhang, Nan Guo, Phung Gip, Siddhartha S. Mitra, and Irving L. Weissman
Physical detection of influenza A epitopes identifies a stealth subset on human lung epithelium evading natural CD8 immunity
Derin B. Keskin, Bruce B. Reinhold, Guang Lan Zhang, Alexander R. Ivanov, Barry L. Karger, and Ellis L. Reinherz
Aberrant recombination and repair during immunoglobulin class switching in BRCA1-deficient human B cells Open Access Article
Andrea Björkman, Per Qvist, Likun Du, Margarita Bartish, Apostolos Zaravinos, Konstantinos Georgiou, Anders D. Børglum, Richard A. Gatti, Therese Törngren, and Qiang Pan-Hammarström
IL-4 abrogates TH17 cell-mediated inflammation by selective silencing of IL-23 in antigen-presenting cells Open Access Article
Emmanuella Guenova, Yuliya Skabytska, Wolfram Hoetzenecker, Günther Weindl, Karin Sauer, Manuela Tham, Kyu-Won Kim, Ji-Hyeon Park, Ji Hae Seo, Desislava Ignatova, Antonio Cozzio, Mitchell P. Levesque, Thomas Volz, Martin Köberle, Susanne Kaesler, Peter Thomas, Reinhard Mailhammer, Kamran Ghoreschi, Knut Schäkel, Boyko Amarov, Martin Eichner, Martin Schaller, Rachael A. Clark, Martin Röcken, and Tilo Biedermann
Medical Sciences
Adverse childhood experiences and physiological wear-and-tear in midlife: Findings from the 1958 British birth cohort
Cristina Barboza Solís, Michelle Kelly-Irving, Romain Fantin, Muriel Darnaudéry, Jérôme Torrisani, Thierry Lang, and Cyrille Delpierre
Gold–silica quantum rattles for multimodal imaging and therapy
Mathew Hembury, Ciro Chiappini, Sergio Bertazzo, Tammy L. Kalber, Glenna L. Drisko, Olumide Ogunlade, Simon Walker-Samuel, Katla Sai Krishna, Coline Jumeaux, Paul Beard, Challa S. S. R. Kumar, Alexandra E. Porter, Mark F. Lythgoe, Cédric Boissière, Clément Sanchez, and Molly M. Stevens
TCL1 targeting miR-3676 is codeleted with tumor protein p53 in chronic lymphocytic leukemia
Veronica Balatti, Lara Rizzotto, Cecelia Miller, Alexey Palamarchuk, Paolo Fadda, Rosantony Pandolfo, Laura Z. Rassenti, Erin Hertlein, Amy S. Ruppert, Arletta Lozanski, Gerard Lozanski, Thomas J. Kipps, John C. Byrd, Carlo M. Croce, and Yuri Pekarsky
Microbiology
An HD-domain phosphodiesterase mediates cooperative hydrolysis of c-di-AMP to affect bacterial growth and virulence
TuAnh Ngoc Huynh, Shukun Luo, Daniel Pensinger, John-Demian Sauer, Liang Tong, and Joshua J. Woodward
Novel mixed-linkage β-glucan activated by c-di-GMP in Sinorhizobium meliloti
Daniel Pérez-Mendoza, Miguel Ángel Rodríguez-Carvajal, Lorena Romero-Jiménez, Gabriela de Araujo Farias, Javier Lloret, María Trinidad Gallegos, and Juan Sanjuán
Differential RNA-seq of Vibrio cholerae identifies the VqmR small RNA as a regulator of biofilm formation
Kai Papenfort, Konrad U. Förstner, Jian-Ping Cong, Cynthia M. Sharma, and Bonnie L. Bassler
Age-related immune clearance of hepatitis B virus infection requires the establishment of gut microbiota
Han-Hsuan Chou, Wei-Hung Chien, Li-Ling Wu, Chi-Hung Cheng, Chen-Han Chung, Jau-Haw Horng, Yen-Hsuan Ni, Hong-Tai Tseng, Dafei Wu, Xuemei Lu, Hurng-Yi Wang, Pei-Jer Chen, and Ding-Shinn Chen
Generation of reactive oxygen species by lethal attacks from competing microbes
Tao G. Dong, Shiqi Dong, Christy Catalano, Richard Moore, Xiaoye Liang, and John J. Mekalanos
Quorum sensing and policing of Pseudomonas aeruginosa social cheaters
Meizhen Wang, Amy L. Schaefer, Ajai A. Dandekar, and E. Peter Greenberg
Characterization of nonprimate hepacivirus and construction of a functional molecular clone
Troels K. H. Scheel, Amit Kapoor, Eiko Nishiuchi, Kenny V. Brock, Yingpu Yu, Linda Andrus, Meigang Gu, Randall W. Renshaw, Edward J. Dubovi, Sean P. McDonough, Gerlinde R. Van de Walle, W. Ian Lipkin, Thomas J. Divers, Bud C. Tennant, and Charles M. Rice
Cross-talk and regulatory interactions between the essential response regulator RpaB and cyanobacterial circadian clock output
Javier Espinosa, Joseph S. Boyd, Raquel Cantos, Paloma Salinas, Susan S. Golden, and Asuncion Contreras
An intermolecular electrostatic interaction controls the prepore-to-pore transition in a cholesterol-dependent cytolysin
Kristin R. Wade, Eileen M. Hotze, Michael J. Kuiper, Craig J. Morton, Michael W. Parker, and Rodney K. Tweten
Noncanonical coproporphyrin-dependent bacterial heme biosynthesis pathway that does not use protoporphyrin
Harry A. Dailey, Svetlana Gerdes, Tamara A. Dailey, Joseph S. Burch, and John D. Phillips
TCF1 and LEF1 act as T-cell intrinsic HTLV-1 antagonists by targeting Tax
Guangyong Ma, Jun-ichirou Yasunaga, Hirofumi Akari, and Masao Matsuoka
N2 gas is an effective fertilizer for bioethanol production by Zymomonas mobilis
Timothy A. Kremer, Breah LaSarre, Amanda L. Posto, and James B. McKinlay
Revealing the density of encoded functions in a viral RNA Open Access Article
Nikesh Patel, Eric C. Dykeman, Robert H. A. Coutts, George P. Lomonossoff, David J. Rowlands, Simon E. V. Phillips, Neil Ranson, Reidun Twarock, Roman Tuma, and Peter G. Stockley
Neuroscience
Two-photon brightness of azobenzene photoswitches designed for glutamate receptor optogenetics
Elizabeth C. Carroll, Shai Berlin, Joshua Levitz, Michael A. Kienzler, Zhe Yuan, Dorte Madsen, Delmar S. Larsen, and Ehud Y. Isacoff
Self-affirmation alters the brain's response to health messages and subsequent behavior change
Emily B. Falk, Matthew Brook O'Donnell, Christopher N. Cascio, Francis Tinney, Yoona Kang, Matthew D. Lieberman, Shelley E. Taylor, Lawrence An, Kenneth Resnicow, and Victor J. Strecher
Behavioral training reverses global cortical network dysfunction induced by perinatal antidepressant exposure
Xiaoming Zhou, Jordan Y.-F. Lu, Ryan D. Darling, Kimberly L. Simpson, Xiaoqing Zhu, Fang Wang, Liping Yu, Xinde Sun, Michael M. Merzenich, and Rick C. S. Lin
Rescue of homeostatic regulation of striatal excitability and locomotor activity in a mouse model of Huntington's disease Open Access Article
Yumei Cao, David Bartolomé-Martín, Naama Rotem, Carlos Rozas, Shlomo S. Dellal, Marcelo A. Chacon, Bashkim Kadriu, Maria Gulinello, Kamran Khodakhah, and Donald S. Faber
CRYPTOCHROME-mediated phototransduction by modulation of the potassium ion channel β-subunit redox sensor Open Access Article
Keri J. Fogle, Lisa S. Baik, Jerry H. Houl, Tri T. Tran, Logan Roberts, Nicole A. Dahm, Yu Cao, Ming Zhou, and Todd C. Holmes
Plasma butyrylcholinesterase regulates ghrelin to control aggression Open Access Article
Vicky Ping Chen, Yang Gao, Liyi Geng, Robin J. Parks, Yuan-Ping Pang, and Stephen Brimijoin
Pharmacology
Regulator of G protein signaling 6 is a critical mediator of both reward-related behavioral and pathological responses to alcohol
Adele Stewart, Biswanath Maity, Simon P. Anderegg, Chantal Allamargot, Jianqi Yang, and Rory A. Fisher
Physiology
Potassium channelopathy-like defect underlies early-stage cerebrovascular dysfunction in a genetic model of small vessel disease
Fabrice Dabertrand, Christel Krøigaard, Adrian D. Bonev, Emmanuel Cognat, Thomas Dalsgaard, Valérie Domenga-Denier, David C. Hill-Eubanks, Joseph E. Brayden, Anne Joutel, and Mark T. Nelson
A fluid secretion pathway unmasked by acinar-specific Tmem16A gene ablation in the adult mouse salivary gland
Marcelo A. Catalán, Yusuke Kondo, Gaspar Peña-Munzenmayer, Yasna Jaramillo, Frances Liu, Sooji Choi, Edward Crandall, Zea Borok, Per Flodby, Gary E. Shull, and James E. Melvin
Plant Biology
An early secretory pathway mediated by GNOM-LIKE 1 and GNOM is essential for basal polarity establishment in Arabidopsis thaliana Open Access Article
Siamsa M. Doyle, Ash Haeger, Thomas Vain, Adeline Rigal, Corrado Viotti, Małgorzata Łangowska, Qian Ma, Jiří Friml, Natasha V. Raikhel, Glenn R. Hicks, and Stéphanie Robert
A methyltransferase required for proper timing of the vernalization response in Arabidopsis
Joohyun Lee, Jae-Young Yun, Wei Zhao, Wen-Hui Shen, and Richard M. Amasino
Auxin binding protein 1 (ABP1) is not required for either auxin signaling or Arabidopsis development
Yangbin Gao, Yi Zhang, Da Zhang, Xinhua Dai, Mark Estelle, and Yunde Zhao
Psychological and Cognitive Sciences
Role of the motor system in language knowledge
Iris Berent, Anna-Katharine Brem, Xu Zhao, Erica Seligson, Hong Pan, Jane Epstein, Emily Stern, Albert M. Galaburda, and Alvaro Pascual-Leone
Sustainability Science
Rapid loss of lakes on the Mongolian Plateau
Shengli Tao, Jingyun Fang, Xia Zhao, Shuqing Zhao, Haihua Shen, Huifeng Hu, Zhiyao Tang, Zhiheng Wang, and Qinghua Guo
Systems Biology
Highly multiplexed profiling of single-cell effector functions reveals deep functional heterogeneity in response to pathogenic ligands
Yao Lu, Qiong Xue, Markus R. Eisele, Endah S. Sulistijo, Kara Brower, Lin Han, El-ad David Amir, Dana Pe'er, Kathryn Miller-Jensen, and Rong Fan
A strategy for tissue self-organization that is robust to cellular heterogeneity and plasticity
Alec E. Cerchiari, James C. Garbe, Noel Y. Jee, Michael E. Todhunter, Kyle E. Broaders, Donna M. Peehl, Tejal A. Desai, Mark A. LaBarge, Matthew Thomson, and Zev J. Gartner

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