Fwd: PNAS Early Edition for 13 Jun 2014

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Proceedings of the National Academy of Sciences Early Edition articles for 13 June 2014 Letters (Online Only) Systemic addiction to research funding Andrew Resnick Systemic flaws cannot be fixed with minor tweaks Steven M. Cuss Rescuing US biomedical research: Some comments on Alberts, Kirschner, Tilghman, and Varmus Thomas Kelly and Kenneth Marians Assessing the implications on air pollution of an alternative control-based criterion Luis Antonio López, Maria Ángeles Cadarso, Jorge Enrique Zafrilla, and Guadalupe Arce Reply to Lopez et al.: Consumption-based accounting helps mitigate global air pollution Dabo Guan, Jintai Lin, Steven J. Davis, Da Pan, Kebin He, Can Wang, Donald J. Wuebbles, David G. Streets, and Qiang Zhang Let's exploit available knowledge on vegetation fluorescence Federico Magnani, Sabrina Raddi, Gina Mohammed, and Elizabeth M. Middleton Reply to Magnani et al.: Linking large-scale chlorophyll fluorescence observations with cropland gross primary production Luis Guanter, Yongguang Zhang, Martin Jung, Joanna Joiner, Maximilian Voigt, Joseph A. Berry, Christian Frankenberg, Alfredo R. Huete, Pablo Zarco-Tejada, Jung-Eun Lee, M. Susan Moran, Guillermo Ponce-Campos, Christian Beer, Gustavo Camps-Valls, Nina Buchmann, Damiano Gianelle, Katja Klumpp, Alessandro Cescatti, John M. Baker, and Timothy J. Griffis Carefully thinking about telomeres Stacy Drury and Katherine Theall Reply to Drury and Theall: No evidence of population stratification Colter Mitchell and Daniel Notterman Anti-HIV drug particles may overcome lymphatic drug insufficiency and associated HIV persistence Jennifer P. Freeling and Rodney J. Y. Ho QnAs QnAs with Thomas Jessell Prashant Nair Commentaries In pursuit of an inhibitory drug for the proton channel Amaury Pupo and Carlos Gonzalez León Redemption of autoreactive B cells Barton F. Haynes, Laurent Verkoczy, and Garnett Kelsoe Predation reduces visual communication distance in an Anolis lizard H. Carl Gerhardt Origins of caprine herding Douglas Baird How season and serotype determine dengue transmissibility Neil M. Ferguson and Derek A. T. Cummings A piggyBac route to transgenic honeybees Yehuda Ben-Shahar Exoplanets Special Feature (free online) Physical Sciences — Astronomy - Biological Sciences — Environmental Sciences Requirements and limits for life in the context of exoplanets Christopher P. McKay Physical Sciences Applied Physical Sciences Pressure-enabled phonon engineering in metals  Nicholas A. Lanzillo, Jay B. Thomas, Bruce Watson, Morris Washington, and Saroj K. Nayak Compositional landscape for glass formation in metal alloys Jong Hyun Na, Marios D. Demetriou, Michael Floyd, Andrew Hoff, Glenn R. Garrett, and William L. Johnson Packing density of rigid aggregates is independent of scale Christopher D. Zangmeister, James G. Radney, Lance T. Dockery, Jessica T. Young, Xiaofei Ma, Rian You, and Michael R. Zachariah Chemistry Correlating the motion of electrons and nuclei with two-dimensional electronic–vibrational spectroscopy  Thomas A. A. Oliver, Nicholas H. C. Lewis, and Graham R. Fleming Mechanism of staphylococcal multiresistance plasmid replication origin assembly by the RepA protein Maria A. Schumacher, Nam K. Tonthat, Stephen M. Kwong, Naga babu Chinnam, Michael A. Liu, Ronald A. Skurray, and Neville Firth Energy landscape of self-assembled superlattices of PbSe nanocrystals Zewei Quan, Di Wu, Jinlong Zhu, Wiel H. Evers, James M. Boncella, Laurens D. A. Siebbeles, Zhongwu Wang, Alexandra Navrotsky, and Hongwu Xu Self-assembly of amphiphilic Janus dendrimers into uniform onion-like dendrimersomes with predictable size and number of bilayers Shaodong Zhang, Hao-Jan Sun, Andrew D. Hughes, Ralph-Olivier Moussodia, Annabelle Bertin, Yingchao Chen, Darrin J. Pochan, Paul A. Heiney, Michael L. Klein, and Virgil Percec Plasticity of hydrogen bond networks regulates mechanochemistry of cell adhesion complexes Shaon Chakrabarti, Michael Hinczewski, and D. Thirumalai Spectroscopic and computational insight into the activation of O2 by the mononuclear Cu center in polysaccharide monooxygenases Christian H. Kjaergaard, Munzarin F. Qayyum, Shaun D. Wong, Feng Xu, Glyn R. Hemsworth, Daniel J. Walton, Nigel A. Young, Gideon J. Davies, Paul H. Walton, Katja Salomon Johansen, Keith O. Hodgson, Britt Hedman, and Edward I. Solomon Water-mediated ion–ion interactions are enhanced at the water vapor–liquid interface Vasudevan Venkateshwaran, Srivathsan Vembanur, and Shekhar Garde Pathway for Mn-cluster oxidation by tyrosine-Z in the S2 state of photosystem II Daniele Narzi, Daniele Bovi, and Leonardo Guidoni Photoinduced transformations of stiff-stilbene-based discrete metallacycles to metallosupramolecular polymers Xuzhou Yan, Jiang-Fei Xu, Timothy R. Cook, Feihe Huang, Qing-Zheng Yang, Chen-Ho Tung, and Peter J. Stang In situ selectivity profiling and crystal structure of SML-8-73-1, an active site inhibitor of oncogenic K-Ras G12C John C. Hunter, Deepak Gurbani, Scott B. Ficarro, Martin A. Carrasco, Sang Min Lim, Hwan Geun Choi, Ting Xie, Jarrod A. Marto, Zhe Chen, Nathanael S. Gray, and Kenneth D. Westover Earth, Atmospheric, and Planetary Sciences Sources and sinks of carbonyl sulfide in an agricultural field in the Southern Great Plains Kadmiel Maseyk, Joseph A. Berry, Dave Billesbach, John Elliott Campbell, Margaret S. Torn, Mark Zahniser, and Ulli Seibt Evidence for elevated and spatially variable geothermal flux beneath the West Antarctic Ice Sheet  Dustin M. Schroeder, Donald D. Blankenship, Duncan A. Young, and Enrica Quartini Proterozoic oxygen rise linked to shifting balance between seafloor and terrestrial weathering  Benjamin Mills, Timothy M. Lenton, and Andrew J. Watson Deep mantle structure as a reference frame for movements in and on the Earth Trond H. Torsvik, Rob van der Voo, Pavel V. Doubrovine, Kevin Burke, Bernhard Steinberger, Lewis D. Ashwal, Reidar G. Trønnes, Susan J. Webb, and Abigail L. Bull Antarctic sea ice control on ocean circulation in present and glacial climates  Raffaele Ferrari, Malte F. Jansen, Jess F. Adkins, Andrea Burke, Andrew L. Stewart, and Andrew F. Thompson Local versus basin-scale limitation of marine nitrogen fixation  Thomas Weber and Curtis Deutsch Mathematics Topologically protected states in one-dimensional continuous systems and Dirac points Charles L. Fefferman, James P. Lee-Thorp, and Michael I. Weinstein Physics Condensation and localization of the partitioning protein ParB on the bacterial chromosome Chase P. Broedersz, Xindan Wang, Yigal Meir, Joseph J. Loparo, David Z. Rudner, and Ned S. Wingreen Coupled counterrotating polariton condensates in optically defined annular potentials Alexander Dreismann, Peter Cristofolini, Ryan Balili, Gabriel Christmann, Florian Pinsker, Natasha G. Berloff, Zacharias Hatzopoulos, Pavlos G. Savvidis, and Jeremy J. Baumberg Slow slip and the transition from fast to slow fronts in the rupture of frictional interfaces Jørgen Kjoshagen Trømborg, Henrik Andersen Sveinsson, Julien Scheibert, Kjetil Thøgersen, David Skålid Amundsen, and Anders Malthe-Sørenssen Sustainability Science Global metaanalysis of the nonlinear response of soil nitrous oxide (N2O) emissions to fertilizer nitrogen  Iurii Shcherbak, Neville Millar, and G. Philip Robertson Social Sciences Psychological and Cognitive Sciences Social identification moderates the effect of crowd density on safety at the Hajj Hani Alnabulsi and John Drury Economic scarcity alters the perception of race Amy R. Krosch and David M. Amodio Oxytocin promotes social bonding in dogs Teresa Romero, Miho Nagasawa, Kazutaka Mogi, Toshikazu Hasegawa, and Takefumi Kikusui Way-finding in displaced clock-shifted bees proves bees use a cognitive map James F. Cheeseman, Craig D. Millar, Uwe Greggers, Konstantin Lehmann, Matthew D. M. Pawley, Charles R. Gallistel, Guy R. Warman, and Randolf Menzel Processing multiple visual objects is limited by overlap in neural channels Michael A. Cohen, Talia Konkle, Juliana Y. Rhee, Ken Nakayama, and George A. Alvarez Female hurricanes are deadlier than male hurricanes Kiju Jung, Sharon Shavitt, Madhu Viswanathan, and Joseph M. Hilbe Experimental evidence of massive-scale emotional contagion through social networks  Adam D. I. Kramer, Jamie E. Guillory, and Jeffrey T. Hancock Biological Sciences Agricultural Sciences The Irish potato famine pathogen Phytophthora infestans originated in central Mexico rather than the Andes Erica M. Goss, Javier F. Tabima, David E. L. Cooke, Silvia Restrepo, William E. Fry, Gregory A. Forbes, Valerie J. Fieland, Martha Cardenas, and Niklaus J. Grünwald Applied Biological Sciences Structural and functional insight into TAF1–TAF7, a subcomplex of transcription factor II D Suparna Bhattacharya, Xiaohua Lou, Peter Hwang, Kanagalaghatta R. Rajashankar, Xiaoping Wang, Jan-Åke Gustafsson, Robert J. Fletterick, Raymond H. Jacobson, and Paul Webb Nuclear receptor TLX stimulates hippocampal neurogenesis and enhances learning and memory in a transgenic mouse model Kiyohito Murai, Qiuhao Qu, GuoQiang Sun, Peng Ye, Wendong Li, Grace Asuelime, Emily Sun, Guochuan E. Tsai, and Yanhong Shi Integration of bacterial lytic polysaccharide monooxygenases into designer cellulosomes promotes enhanced cellulose degradation Yonathan Arfi, Melina Shamshoum, Ilana Rogachev, Yoav Peleg, and Edward A. Bayer Influenza hemagglutinin stem-fragment immunogen elicits broadly neutralizing antibodies and confers heterologous protection Vamsee V. A. Mallajosyula, Michael Citron, Francesca Ferrara, Xianghan Lu, Cheryl Callahan, Gwendolyn J. Heidecker, Siddhartha P. Sarma, Jessica A. Flynn, Nigel J. Temperton, Xiaoping Liang, and Raghavan Varadarajan Genetically engineering Synechocystis sp. Pasteur Culture Collection 6803 for the sustainable production of the plant secondary metabolite p-coumaric acid Yong Xue, Yan Zhang, Dan Cheng, Soumana Daddy, and Qingfang He Biochemistry Structure of an antibacterial peptide ATP-binding cassette transporter in a novel outward occluded state  Hassanul G. Choudhury, Zhen Tong, Indran Mathavan, Yanyan Li, So Iwata, Séverine Zirah, Sylvie Rebuffat, Hendrik W. van Veen, and Konstantinos Beis Structural and mechanistic studies of polymerase η bypass of phenanthriplatin DNA damage Mark T. Gregory, Ga Young Park, Timothy C. Johnstone, Young-Sam Lee, Wei Yang, and Stephen J. Lippard Mechanism of staphylococcal multiresistance plasmid replication origin assembly by the RepA protein Maria A. Schumacher, Nam K. Tonthat, Stephen M. Kwong, Naga babu Chinnam, Michael A. Liu, Ronald A. Skurray, and Neville Firth Taura syndrome virus IRES initiates translation by binding its tRNA-mRNA–like structural element in the ribosomal decoding center Cha San Koh, Axel F. Brilot, Nikolaus Grigorieff, and Andrei A. Korostelev Vesiculoviral matrix (M) protein occupies nucleic acid binding site at nucleoporin pair (Rae1•Nup98)  Beili Quan, Hyuk-Soo Seo, Günter Blobel, and Yi Ren Spectroscopic and computational insight into the activation of O2 by the mononuclear Cu center in polysaccharide monooxygenases Christian H. Kjaergaard, Munzarin F. Qayyum, Shaun D. Wong, Feng Xu, Glyn R. Hemsworth, Daniel J. Walton, Nigel A. Young, Gideon J. Davies, Paul H. Walton, Katja Salomon Johansen, Keith O. Hodgson, Britt Hedman, and Edward I. Solomon Engineering of a red-light–activated human cAMP/cGMP-specific phosphodiesterase Carlos Gasser, Sandra Taiber, Chen-Min Yeh, Charlotte Helene Wittig, Peter Hegemann, Soojin Ryu, Frank Wunder, and Andreas Möglich Methylated glycans as conserved targets of animal and fungal innate defense Therese Wohlschlager, Alex Butschi, Paola Grassi, Grigorij Sutov, Robert Gauss, Dirk Hauck, Stefanie S. Schmieder, Martin Knobel, Alexander Titz, Anne Dell, Stuart M. Haslam, Michael O. Hengartner, Markus Aebi, and Markus Künzler Biophysics and Computational Biology Cofactor-dependent conformational heterogeneity of GAD65 and its role in autoimmunity and neurotransmitter homeostasis Itamar Kass, David E. Hoke, Mauricio G. S. Costa, Cyril F. Reboul, Benjamin T. Porebski, Nathan P. Cowieson, Hervé Leh, Eugenia Pennacchietti, Julia McCoey, Oded Kleifeld, Carla Borri Voltattorni, David Langley, Brendan Roome, Ian R. Mackay, Daniel Christ, David Perahia, Malcolm Buckle, Alessandro Paiardini, Daniela De Biase, and Ashley M. Buckle Plasticity of hydrogen bond networks regulates mechanochemistry of cell adhesion complexes Shaon Chakrabarti, Michael Hinczewski, and D. Thirumalai Taxodione and arenarone inhibit farnesyl diphosphate synthase by binding to the isopentenyl diphosphate site Yi-Liang Liu, Steffen Lindert, Wei Zhu, Ke Wang, J. Andrew McCammon, and Eric Oldfield Condensation and localization of the partitioning protein ParB on the bacterial chromosome Chase P. Broedersz, Xindan Wang, Yigal Meir, Joseph J. Loparo, David Z. Rudner, and Ned S. Wingreen Measuring hydrogen exchange rates in invisible protein excited states Dong Long, Guillaume Bouvignies, and Lewis E. Kay Single-particle EM reveals plasticity of interactions between the adenovirus penton base and integrin αVβ3 David Veesler, Karolina Cupelli, Markus Burger, Peter Gräber, Thilo Stehle, and John E. Johnson Cell Biology An iron-regulated and glycosylation-dependent proteasomal degradation pathway for the plasma membrane metal transporter ZIP14 Ningning Zhao, An-Sheng Zhang, Christal Worthen, Mitchell D. Knutson, and Caroline A. Enns Perilipins 2 and 3 lack a carboxy-terminal domain present in perilipin 1 involved in sequestering ABHD5 and suppressing basal lipolysis Satish Patel, Wei Yang, Kristina Kozusko, Vladimir Saudek, and David B. Savage Targeting c-MYC by antagonizing PP2A inhibitors in breast cancer Mahnaz Janghorban, Amy S. Farrell, Brittany L. Allen-Petersen, Carl Pelz, Colin J. Daniel, Jessica Oddo, Ellen M. Langer, Dale J. Christensen, and Rosalie C. Sears Primary cilia control hedgehog signaling during muscle differentiation and are deregulated in rhabdomyosarcoma Wenxiang Fu, Patrik Asp, Brian Canter, and Brian David Dynlacht DNA double-strand breaks promote methylation of histone H3 on lysine 9 and transient formation of repressive chromatin  Marina K. Ayrapetov, Ozge Gursoy-Yuzugullu, Chang Xu, Ye Xu, and Brendan D. Price Probing nuclear pore complex architecture with proximity-dependent biotinylation Dae In Kim, Birendra KC, Wenhong Zhu, Khatereh Motamedchaboki, Valérie Doye, and Kyle J. Roux Contact inhibition and high cell density deactivate the mammalian target of rapamycin pathway, thus suppressing the senescence program Olga V. Leontieva, Zoya N. Demidenko, and Mikhail V. Blagosklonny Single-cell nucleosome mapping reveals the molecular basis of gene expression heterogeneity  Eliza C. Small, Liqun Xi, Ji-Ping Wang, Jonathan Widom, and Jonathan D. Licht NAD+ and SIRT3 control microtubule dynamics and reduce susceptibility to antimicrotubule agents William T. Harkcom, Ananda K. Ghosh, Matthew S. Sung, Alexandre Matov, Kevin D. Brown, Paraskevi Giannakakou, and Samie R. Jaffrey Skp1-Cullin-F-box (SCF)-type ubiquitin ligase FBXW7 negatively regulates spermatogonial stem cell self-renewal Mito Kanatsu-Shinohara, Ichiro Onoyama, Keiichi I. Nakayama, and Takashi Shinohara Developmental Biology Pitx2-microRNA pathway that delimits sinoatrial node development and inhibits predisposition to atrial fibrillation Jun Wang, Yan Bai, Na Li, Wenduo Ye, Min Zhang, Stephanie B. Greene, Ye Tao, Yiping Chen, Xander H. T. Wehrens, and James F. Martin Notch regulation of myogenic versus endothelial fates of cells that migrate from the somite to the limb Alicia Mayeuf-Louchart, Mounia Lagha, Anne Danckaert, Didier Rocancourt, Frederic Relaix, Stéphane D. Vincent, and Margaret Buckingham The endocannabinoid 2-AG controls skeletal muscle cell differentiation via CB1 receptor-dependent inhibition of Kv7 channels Fabio A. Iannotti, Cristoforo Silvestri, Enrico Mazzarella, Andrea Martella, Daniela Calvigioni, Fabiana Piscitelli, Paolo Ambrosino, Stefania Petrosino, Gabriella Czifra, Tamás Bíró, Tibor Harkany, Maurizio Taglialatela, and Vincenzo Di Marzo Ecology Badger responses to small-scale culling may compromise targeted control of bovine tuberculosis Jon Bielby, Christl A. Donnelly, Lisa C. Pope, Terry Burke, and Rosie Woodroffe Anthropogenic changes in sodium affect neural and muscle development in butterflies Emilie C. Snell-Rood, Anne Espeset, Christopher J. Boser, William A. White, and Rhea Smykalski Steeper declines in forest photosynthesis than respiration explain age-driven decreases in forest growth Jianwu Tang, Sebastiaan Luyssaert, Andrew D. Richardson, Werner Kutsch, and Ivan A. Janssens Environmental Sciences Global metaanalysis of the nonlinear response of soil nitrous oxide (N2O) emissions to fertilizer nitrogen  Iurii Shcherbak, Neville Millar, and G. Philip Robertson Evolution Medically important differences in snake venom composition are dictated by distinct postgenomic mechanisms  Nicholas R. Casewell, Simon C. Wagstaff, Wolfgang Wüster, Darren A. N. Cook, Fiona M. S. Bolton, Sarah I. King, Davinia Pla, Libia Sanz, Juan J. Calvete, and Robert A. Harrison Genetics Maritime route of colonization of Europe  Peristera Paschou, Petros Drineas, Evangelia Yannaki, Anna Razou, Katerina Kanaki, Fotis Tsetsos, Shanmukha Sampath Padmanabhuni, Manolis Michalodimitrakis, Maria C. Renda, Sonja Pavlovic, Achilles Anagnostopoulos, John A. Stamatoyannopoulos, Kenneth K. Kidd, and George Stamatoyannopoulos Immunology Human memory T cells from the bone marrow are resting and maintain long-lasting systemic memory  Anna Okhrimenko, Joachim R. Grün, Kerstin Westendorf, Zhuo Fang, Simon Reinke, Philipp von Roth, Georgi Wassilew, Anja A. Kühl, Robert Kudernatsch, Sonya Demski, Carmen Scheibenbogen, Koji Tokoyoda, Mairi A. McGrath, Martin J. Raftery, Günther Schönrich, Alessandro Serra, Hyun-Dong Chang, Andreas Radbruch, and Jun Dong An evolving autoimmune microenvironment regulates the quality of effector T cell restimulation and function Rachel S. Friedman, Robin S. Lindsay, Jason K. Lilly, Vinh Nguyen, Caitlin M. Sorensen, Jordan Jacobelli, and Matthew F. Krummel Antigen expression level threshold tunes the fate of CD8 T cells during primary hepatic immune responses Szun Szun Tay, Yik Chun Wong, David M. McDonald, Nicole A. W. Wood, Ben Roediger, Frederic Sierro, Claire Mcguffog, Ian E. Alexander, G. Alex Bishop, Jennifer R. Gamble, Wolfgang Weninger, Geoffrey W. McCaughan, Patrick Bertolino, and David G. Bowen Distinct phases in the positive selection of CD8+ T cells distinguished by intrathymic migration and T-cell receptor signaling patterns Jenny O. Ross, Heather J. Melichar, Byron B. Au-Yeung, Paul Herzmark, Arthur Weiss, and Ellen A. Robey Nod/Ripk2 signaling in dendritic cells activates IL-17A–secreting innate lymphoid cells and drives colitis in T-bet−/−.Rag2−/− (TRUC) mice Joerg Ermann, Tracy Staton, Jonathan N. Glickman, Rene de Waal Malefyt, and Laurie H. Glimcher Differential expression of APE1 and APE2 in germinal centers promotes error-prone repair and A:T mutations during somatic hypermutation Janet Stavnezer, Erin K. Linehan, Mikayla R. Thompson, Ghaith Habboub, Anna J. Ucher, Tatenda Kadungure, Daisuke Tsuchimoto, Yusaku Nakabeppu, and Carol E. Schrader Evolution of TNF-induced apoptosis reveals 550 My of functional conservation  Steven D. Quistad, Aleksandr Stotland, Katie L. Barott, Cameron A. Smurthwaite, Brett Jameson Hilton, Juris A. Grasis, Roland Wolkowicz, and Forest L. Rohwer Structural basis for simultaneous recognition of an O-glycan and its attached peptide of mucin family by immune receptor PILRα Kimiko Kuroki, Jing Wang, Toyoyuki Ose, Munechika Yamaguchi, Shigekazu Tabata, Nobuo Maita, Seiko Nakamura, Mizuho Kajikawa, Amane Kogure, Takeshi Satoh, Hisashi Arase, and Katsumi Maenaka Differential role of nonhomologous end joining factors in the generation, DNA damage response, and myeloid differentiation of human induced pluripotent stem cells Kerstin Felgentreff, Likun Du, Katja G. Weinacht, Kerry Dobbs, Margarita Bartish, Silvia Giliani, Thorsten Schlaeger, Alexander DeVine, Axel Schambach, Lisa J. Woodbine, Graham Davies, Sachin N. Baxi, Mirjam van der Burg, Jack Bleesing, Andrew Gennery, John Manis, Qiang Pan-Hammarström, and Luigi D. Notarangelo The GTPase-activating protein GIT2 protects against colitis by negatively regulating Toll-like receptor signaling Juncheng Wei, Chao Wei, Min Wang, Xiao Qiu, Yang Li, Yanzhi Yuan, Chaozhi Jin, Ling Leng, Jian Wang, Xiaoming Yang, and Fuchu He Medical Sciences Chem-seq permits identification of genomic targets of drugs against androgen receptor regulation selected by functional phenotypic screens  Chunyu Jin, Liuqing Yang, Min Xie, Chunru Lin, Daria Merkurjev, Joy C. Yang, Bogdan Tanasa, Soohwan Oh, Jie Zhang, Kenneth A. Ohgi, Hongyan Zhou, Wenbo Li, Christopher P. Evans, Sheng Ding, and Michael G. Rosenfeld Seamless modification of wild-type induced pluripotent stem cells to the natural CCR5Δ32 mutation confers resistance to HIV infection Lin Ye, Jiaming Wang, Ashley I. Beyer, Fernando Teque, Thomas J. Cradick, Zhongxia Qi, Judy C. Chang, Gang Bao, Marcus O. Muench, Jingwei Yu, Jay A. Levy, and Yuet Wai Kan Regulation of cell proliferation and migration by p62 through stabilization of Twist1 Lei Qiang, Baozhong Zhao, Mei Ming, Ning Wang, Tong-Chuan He, Seungmin Hwang, Andrew Thorburn, and Yu-Ying He Targeting and in vivo imaging of non-small–cell lung cancer using nebulized multimodal contrast agents Andrea Bianchi, Sandrine Dufort, François Lux, Pierre-Yves Fortin, Nawal Tassali, Olivier Tillement, Jean-Luc Coll, and Yannick Crémillieux Targeted inversion and reversion of the blood coagulation factor 8 gene in human iPS cells using TALENs  Chul-Yong Park, Jungeun Kim, Jiyeon Kweon, Jeong Sang Son, Jae Souk Lee, Jeong-Eun Yoo, Sung-Rae Cho, Jong-Hoon Kim, Jin-Soo Kim, and Dong-Wook Kim TM6SF2 is a regulator of liver fat metabolism influencing triglyceride secretion and hepatic lipid droplet content  Hovsep Mahdessian, Apostolos Taxiarchis, Sergej Popov, Angela Silveira, Anders Franco-Cereceda, Anders Hamsten, Per Eriksson, and Ferdinand van't Hooft Combination of bexarotene and the retinoid CD1530 reduces murine oral-cavity carcinogenesis induced by the carcinogen 4-nitroquinoline 1-oxide Xiao-Han Tang, Kwame Osei-Sarfo, Alison M. Urvalek, Tuo Zhang, Theresa Scognamiglio, and Lorraine J. Gudas Mutations disrupting the Kennedy phosphatidylcholine pathway in humans with congenital lipodystrophy and fatty liver disease Felicity Payne, Koini Lim, Amandine Girousse, Rebecca J. Brown, Nora Kory, Ann Robbins, Yali Xue, Alison Sleigh, Elaine Cochran, Claire Adams, Arundhati Dev Borman, David Russel-Jones, Phillip Gorden, Robert K. Semple, Vladimir Saudek, Stephen O'Rahilly, Tobias C. Walther, Inês Barroso, and David B. Savage 11β-HSD1 is the major regulator of the tissue-specific effects of circulating glucocorticoid excess  Stuart A. Morgan, Emma L. McCabe, Laura L. Gathercole, Zaki K. Hassan-Smith, Dean P. Larner, Iwona J. Bujalska, Paul M. Stewart, Jeremy W. Tomlinson, and Gareth G. Lavery In situ selectivity profiling and crystal structure of SML-8-73-1, an active site inhibitor of oncogenic K-Ras G12C John C. Hunter, Deepak Gurbani, Scott B. Ficarro, Martin A. Carrasco, Sang Min Lim, Hwan Geun Choi, Ting Xie, Jarrod A. Marto, Zhe Chen, Nathanael S. Gray, and Kenneth D. Westover Microbiology DNA looping-dependent autorepression of LEE1 P1 promoters by Ler in enteropathogenic Escherichia coli (EPEC)  Abhayprasad Bhat, Minsang Shin, Jae-Ho Jeong, Hyun-Ju Kim, Hyung-Ju Lim, Joon Haeng Rhee, Soon-Young Paik, Kunio Takeyasu, Toru Tobe, Hilo Yen, Gwangrog Lee, and Hyon E. Choy Probing the paramyxovirus fusion (F) protein-refolding event from pre- to postfusion by oxidative footprinting Taylor A. Poor, Lisa M. Jones, Amika Sood, George P. Leser, Manolo D. Plasencia, Don L. Rempel, Theodore S. Jardetzky, Robert J. Woods, Michael L. Gross, and Robert A. Lamb Correcting direct effects of ethanol on translation and transcription machinery confers ethanol tolerance in bacteria  Rembrandt J. F. Haft, David H. Keating, Tyler Schwaegler, Michael S. Schwalbach, Jeffrey Vinokur, Mary Tremaine, Jason M. Peters, Matthew V. Kotlajich, Edward L. Pohlmann, Irene M. Ong, Jeffrey A. Grass, Patricia J. Kiley, and Robert Landick Atlas of nonribosomal peptide and polyketide biosynthetic pathways reveals common occurrence of nonmodular enzymes Hao Wang, David P. Fewer, Liisa Holm, Leo Rouhiainen, and Kaarina Sivonen Marker for type VI secretion system effectors Dor Salomon, Lisa N. Kinch, David C. Trudgian, Xiaofeng Guo, John A. Klimko, Nick V. Grishin, Hamid Mirzaei, and Kim Orth Mycobacterium tuberculosis supports protein tyrosine phosphorylation Ulrike Kusebauch, Corrie Ortega, Anja Ollodart, Richard S. Rogers, David R. Sherman, Robert L. Moritz, and Christoph Grundner GroEL from the endosymbiont Buchnera aphidicola betrays the aphid by triggering plant defense Ritu Chaudhary, Hagop S. Atamian, Zhouxin Shen, Steven P. Briggs, and Isgouhi Kaloshian Transcription is initiated on silent variant surface glycoprotein expression sites despite monoallelic expression in Trypanosoma brucei Ali Kassem, Etienne Pays, and Luc Vanhamme Type I interferon is a therapeutic target for virus-induced lethal vascular damage Roberto Baccala, Megan J. Welch, Rosana Gonzalez-Quintial, Kevin B. Walsh, John R. Teijaro, Anthony Nguyen, Cherie T. Ng, Brian M. Sullivan, Alessandro Zarpellon, Zaverio M. Ruggeri, Juan Carlos de la Torre, Argyrios N. Theofilopoulos, and Michael B. A. Oldstone Direct conversion of plant biomass to ethanol by engineered Caldicellulosiruptor bescii Daehwan Chung, Minseok Cha, Adam M. Guss, and Janet Westpheling Multiplex genome editing by natural transformation Ankur B. Dalia, EmilyKate McDonough, and Andrew Camilli Neuroscience An unusually powerful mode of low-frequency sound interference due to defective hair bundles of the auditory outer hair cells  Kazusaku Kamiya, Vincent Michel, Fabrice Giraudet, Brigitte Riederer, Isabelle Foucher, Samantha Papal, Isabelle Perfettini, Sébastien Le Gal, Elisabeth Verpy, Weiliang Xia, Ursula Seidler, Maria-Magdalena Georgescu, Paul Avan, Aziz El-Amraoui, and Christine Petit Pituitary tumor-transforming gene 1 regulates the patterning of retinal mosaics Patrick W. Keeley, Cuiqi Zhou, Lu Lu, Robert W. Williams, Shlomo Melmed, and Benjamin E. Reese Immersive audiomotor game play enhances neural and perceptual salience of weak signals in noise Jonathon P. Whitton, Kenneth E. Hancock, and Daniel B. Polley Resting GABA and glutamate concentrations do not predict visual gamma frequency or amplitude  Helena Cousijn, Saskia Haegens, George Wallis, Jamie Near, Mark G. Stokes, Paul J. Harrison, and Anna C. Nobre Linear integration of spine Ca2+ signals in layer 4 cortical neurons in vivo Hongbo Jia, Zsuzsanna Varga, Bert Sakmann, and Arthur Konnerth Recovery of consciousness is mediated by a network of discrete metastable activity states  Andrew E. Hudson, Diany Paola Calderon, Donald W. Pfaff, and Alex Proekt Abrogation of α-synuclein–mediated dopaminergic neurodegeneration in LRRK2-deficient rats João P. L. Daher, Laura A. Volpicelli-Daley, Jonathan P. Blackburn, Mark S. Moehle, and Andrew B. West Way-finding in displaced clock-shifted bees proves bees use a cognitive map James F. Cheeseman, Craig D. Millar, Uwe Greggers, Konstantin Lehmann, Matthew D. M. Pawley, Charles R. Gallistel, Guy R. Warman, and Randolf Menzel Protons are a neurotransmitter that regulates synaptic plasticity in the lateral amygdala Jianyang Du, Leah R. Reznikov, Margaret P. Price, Xiang-ming Zha, Yuan Lu, Thomas O. Moninger, John A. Wemmie, and Michael J. Welsh Processing multiple visual objects is limited by overlap in neural channels Michael A. Cohen, Talia Konkle, Juliana Y. Rhee, Ken Nakayama, and George A. Alvarez Synaptic function of nicastrin in hippocampal neurons Sang Hun Lee, Manu Sharma, Thomas C. Südhof, and Jie Shen A spatially nonselective baseline signal in parietal cortex reflects the probability of a monkey's success on the current trial Mingsha Zhang, Xiaolan Wang, and Michael E. Goldberg Manganese-enhanced magnetic resonance imaging reveals increased DOI-induced brain activity in a mouse model of schizophrenia Natalia V. Malkova, Joseph J. Gallagher, Collin Z. Yu, Russell E. Jacobs, and Paul H. Patterson Pharmacology An alcohol-sensing site in the calcium- and voltage-gated, large conductance potassium (BK) channel Anna N. Bukiya, Guruprasad Kuntamallappanavar, Justin Edwards, Aditya K. Singh, Bangalore Shivakumar, and Alex M. 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Nunn Corrections Correction for Rowland and Deeds., Crosstalk and the evolution of specificity in twocomponent signaling Correction for Woo et al., Differential processing of Arabidopsis ubiquitinlike Atg8 autophagy proteins by Atg4 cysteine proteases Correction for Loos et al., Expression and glycoengineering of functionally active heteromultimeric IgM in plants Open Access From the Cover Inaugural Article Classic Cozzarelli Prize Winner Front Matter This message was sent to pascal.alter@gmail.com. (......)  * 425 Broadway St * Redwood City, CA 94063 * U.S.A. Copyright © 2014 by the National Academy of Sciences