Fwd: PNAS Early Edition for 6 Nov 2014

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Subject: PNAS Early Edition for 6 Nov 2014
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Proceedings of the National Academy of Sciences Early Edition articles for 6 November 2014 Letters (Online Only) Using multielement isotopic analysis to decipher drought impacts and adaptive management in ancient agricultural systems Toby M. Maxwell, Lucas C. R. Silva, and William R. Horwath Reply to Maxwell et al.: Stable isotopes and their potential for interpreting archaeobotanical remains Simone Riehl and Konstantin E. Pustovoytov Not surprisingly, no inheritance of a trait results in no evolution Philip W. Hedrick, David W. Coltman, Marco Festa-Bianchet, and Fanie Pelletier Reply to Hedrick et al.: Trophy hunting influences the distribution of trait values through demographic impacts Lochran W. Traill, Susanne Schindler, and Tim Coulson QnAs QnAs with Mary C. Waters Tinsley H. Davis Commentaries Trait-based extinction catches the Red Queen napping during the Cambrian P. David Polly Impact of early-stage HIV transmission on treatment as prevention Kimberly A. Powers, Mirjam E. Kretzschmar, William C. Miller, and Myron S. Cohen Prevalence of cycling genes and drug targets calls for prospective chronotherapeutics Nimish D. Kathale and Andrew C. Liu Closing the sea level budget at the Last Glacial Maximum Peter U. Clark and Lev Tarasov Horizontal transfer beyond genes Eugene V. Koonin Feature Articles Sphericity and symmetry breaking in the formation of Frank–Kasper phases from one component materials  Sangwoo Lee, Chris Leighton, and Frank S. Bates Intracellular metabolite levels shape sulfur isotope fractionation during microbial sulfate respiration Boswell A. Wing and Itay Halevy Physical Sciences Applied Mathematics Deciding whether follow-up studies have replicated findings in a preliminary large-scale omics study  Ruth Heller, Marina Bogomolov, and Yoav Benjamini Applied Physical Sciences Splitting, linking, knotting, and solitonic escape of topological defects in nematic drops with handles Mykola Tasinkevych, Michael G. Campbell, and Ivan I. Smalyukh Acceleration of evolutionary spread by long-range dispersal  Oskar Hallatschek and Daniel S. Fisher Chemistry Copper is an endogenous modulator of neural circuit spontaneous activity Sheel C. Dodani, Alana Firl, Jefferson Chan, Christine I. Nam, Allegra T. Aron, Carl S. Onak, Karla M. Ramos-Torres, Jaeho Paek, Corey M. Webster, Marla B. Feller, and Christopher J. Chang Amino acid modified Ni catalyst exhibits reversible H2 oxidation/production over a broad pH range at elevated temperatures Arnab Dutta, Daniel L. DuBois, John A. S. Roberts, and Wendy J. Shaw Negamycin induces translational stalling and miscoding by binding to the small subunit head domain of the Escherichia coli ribosome  Nelson B. Olivier, Roger B. Altman, Jonas Noeske, Gregory S. Basarab, Erin Code, Andrew D. Ferguson, Ning Gao, Jian Huang, Manuel F. Juette, Stephania Livchak, Matthew D. Miller, D. Bryan Prince, Jamie H. D. Cate, Ed T. Buurman, and Scott C. Blanchard Luminescence color switching of supramolecular assemblies of discrete molecular decanuclear gold(I) sulfido complexes Franky Ka-Wah Hau, Terence Kwok-Ming Lee, Eddie Chung-Chin Cheng, Vonika Ka-Man Au, and Vivian Wing-Wah Yam Earth, Atmospheric, and Planetary Sciences Far-infrared surface emissivity and climate  Daniel R. Feldman, William D. Collins, Robert Pincus, Xianglei Huang, and Xiuhong Chen Topography's crucial role in Heinrich Events William H. G. Roberts, Paul J. Valdes, and Antony J. Payne Late Miocene episodic lakes in the arid Tarim Basin, western China Weiguo Liu, Zhonghui Liu, Zhisheng An, Jimin Sun, Hong Chang, Ning Wang, Jibao Dong, and Huanye Wang Basin-scale estimates of pelagic and coral reef calcification in the Red Sea and Western Indian Ocean  Zvi Steiner, Jonathan Erez, Aldo Shemesh, Ruth Yam, Amitai Katz, and Boaz Lazar Engineering Simple battery armor to protect against gastrointestinal injury from accidental ingestion Bryan Laulicht, Giovanni Traverso, Vikram Deshpande, Robert Langer, and Jeffrey M. Karp Asymmetric hindwing foldings in rove beetles Kazuya Saito, Shuhei Yamamoto, Munetoshi Maruyama, and Yoji Okabe Sustainability Science Disentangling the effects of CO2 and short-lived climate forcer mitigation  Joeri Rogelj, Michiel Schaeffer, Malte Meinshausen, Drew T. Shindell, William Hare, Zbigniew Klimont, Guus J. M. Velders, Markus Amann, and Hans Joachim Schellnhuber Recent climate and air pollution impacts on Indian agriculture  Jennifer Burney and V. Ramanathan Social Sciences Psychological and Cognitive Sciences Decreased segregation of brain systems across the healthy adult lifespan  Micaela Y. Chan, Denise C. Park, Neil K. Savalia, Steven E. Petersen, and Gagan S. Wig Ventromedial prefrontal cortex supports affective future simulation by integrating distributed knowledge Roland G. Benoit, Karl K. Szpunar, and Daniel L. Schacter Probabilistic cognition in two indigenous Mayan groups Laura Fontanari, Michel Gonzalez, Giorgio Vallortigara, and Vittorio Girotto Purpose in life and use of preventive health care services Eric S. Kim, Victor J. Strecher, and Carol D. Ryff Biological Sciences Agricultural Sciences Days to heading 7, a major quantitative locus determining photoperiod sensitivity and regional adaptation in rice  He Gao, Mingna Jin, Xiao-Ming Zheng, Jun Chen, Dingyang Yuan, Yeyun Xin, Maoqing Wang, Dongyi Huang, Zhe Zhang, Kunneng Zhou, Peike Sheng, Jin Ma, Weiwei Ma, Huafeng Deng, Ling Jiang, Shijia Liu, Haiyang Wang, Chuanyin Wu, Longping Yuan, and Jianmin Wan Applied Biological Sciences Asymmetric hindwing foldings in rove beetles Kazuya Saito, Shuhei Yamamoto, Munetoshi Maruyama, and Yoji Okabe Sexual transfer of the steroid hormone 20E induces the postmating switch in Anopheles gambiae  Paolo Gabrieli, Evdoxia G. Kakani, Sara N. Mitchell, Enzo Mameli, Elizabeth J. Want, Ainhoa Mariezcurrena Anton, Aurelio Serrao, Francesco Baldini, and Flaminia Catteruccia Biochemistry Liat1, an arginyltransferase-binding protein whose evolution among primates involved changes in the numbers of its 10-residue repeats Christopher S. Brower, Connor E. Rosen, Richard H. Jones, Brandon C. Wadas, Konstantin I. Piatkov, and Alexander Varshavsky Molecular insights into DNA interference by CRISPR-associated nuclease-helicase Cas3 Bei Gong, Minsang Shin, Jiali Sun, Che-Hun Jung, Edward L. Bolt, John van der Oost, and Jeong-Sun Kim c-Abl tyrosine kinase promotes adipocyte differentiation by targeting PPAR-gamma 2 Rom Keshet, Zina Bryansker Kraitshtein, Matan Shanzer, Julia Adler, Nina Reuven, and Yosef Shaul Differential gradients of interaction affinities drive efficient targeting and recycling in the GET pathway Michael E. Rome, Un Seng Chio, Meera Rao, Harry Gristick, and Shu-ou Shan Calcium-mediated histone modifications regulate alternative splicing in cardiomyocytes Alok Sharma, Hieu Nguyen, Cuiyu Geng, Melissa N. Hinman, Guangbin Luo, and Hua Lou Negamycin induces translational stalling and miscoding by binding to the small subunit head domain of the Escherichia coli ribosome  Nelson B. Olivier, Roger B. Altman, Jonas Noeske, Gregory S. Basarab, Erin Code, Andrew D. Ferguson, Ning Gao, Jian Huang, Manuel F. Juette, Stephania Livchak, Matthew D. Miller, D. Bryan Prince, Jamie H. D. Cate, Ed T. Buurman, and Scott C. Blanchard Goniometer-based femtosecond crystallography with X-ray free electron lasers  Aina E. Cohen, S. Michael Soltis, Ana González, Laura Aguila, Roberto Alonso-Mori, Christopher O. Barnes, Elizabeth L. Baxter, Winnie Brehmer, Aaron S. Brewster, Axel T. Brunger, Guillermo Calero, Joseph F. Chang, Matthieu Chollet, Paul Ehrensberger, Thomas L. Eriksson, Yiping Feng, Johan Hattne, Britt Hedman, Michael Hollenbeck, James M. Holton, Stephen Keable, Brian K. Kobilka, Elena G. Kovaleva, Andrew C. Kruse, Henrik T. Lemke, Guowu Lin, Artem Y. Lyubimov, Aashish Manglik, Irimpan I. Mathews, Scott E. McPhillips, Silke Nelson, John W. Peters, Nicholas K. Sauter, Clyde A. Smith, Jinhu Song, Hilary P. Stevenson, Yingssu Tsai, Monarin Uervirojnangkoorn, Vladimir Vinetsky, Soichi Wakatsuki, William I. Weis, Oleg A. Zadvornyy, Oliver B. Zeldin, Diling Zhu, and Keith O. Hodgson Biophysics and Computational Biology Halorhodopsin pumps Cl– and bacteriorhodopsin pumps protons by a common mechanism that uses conserved electrostatic interactions Yifan Song and M. R. Gunner Cell Biology Copper is an endogenous modulator of neural circuit spontaneous activity Sheel C. Dodani, Alana Firl, Jefferson Chan, Christine I. Nam, Allegra T. Aron, Carl S. Onak, Karla M. Ramos-Torres, Jaeho Paek, Corey M. Webster, Marla B. Feller, and Christopher J. Chang Long-range enhancer activity determines Myc sensitivity to Notch inhibitors in T cell leukemia Yumi Yashiro-Ohtani, Hongfang Wang, Chongzhi Zang, Kelly L. Arnett, Will Bailis, Yugong Ho, Birgit Knoechel, Claudia Lanauze, Lumena Louis, Katherine S. Forsyth, Sujun Chen, Yoonjie Chung, Jonathan Schug, Gerd A. Blobel, Stephen A. Liebhaber, Bradley E. Bernstein, Stephen C. Blacklow, Xiaole Shirley Liu, Jon C. Aster, and Warren S. Pear Microtubules stabilize cell polarity by localizing rear signals Jian Zhang, Wei-Hui Guo, and Yu-Li Wang Actions of the protein kinase WNK1 on endothelial cells are differentially mediated by its substrate kinases OSR1 and SPAK Hashem A. Dbouk, Lauren M. Weil, G. K. Sachith Perera, Michael T. Dellinger, Gray Pearson, Rolf A. Brekken, and Melanie H. Cobb Analysis of clock-regulated genes in Neurospora reveals widespread posttranscriptional control of metabolic potential  Jennifer M. Hurley, Arko Dasgupta, Jillian M. Emerson, Xiaoying Zhou, Carol S. Ringelberg, Nicole Knabe, Anna M. Lipzen, Erika A. Lindquist, Christopher G. Daum, Kerrie W. Barry, Igor V. Grigoriev, Kristina M. Smith, James E. Galagan, Deborah Bell-Pedersen, Michael Freitag, Chao Cheng, Jennifer J. Loros, and Jay C. Dunlap Developmental Biology Single Lgr5- or Lgr6-expressing taste stem/progenitor cells generate taste bud cells ex vivo Wenwen Ren, Brian C. Lewandowski, Jaime Watson, Eitaro Aihara, Ken Iwatsuki, Alexander A. Bachmanov, Robert F. Margolskee, and Peihua Jiang Sexually dimorphic expression of Mafb regulates masculinization of the embryonic urethral formation  Kentaro Suzuki, Tomokazu Numata, Hiroko Suzuki, Dennis Diana Raga, Lerrie Ann Ipulan, Chikako Yokoyama, Shoko Matsushita, Michito Hamada, Naomi Nakagata, Ryuichi Nishinakamura, Shoen Kume, Satoru Takahashi, and Gen Yamada K-RasV14I recapitulates Noonan syndrome in mice Isabel Hernández-Porras, Salvatore Fabbiano, Alberto J. Schuhmacher, Alexandra Aicher, Marta Cañamero, Juan Antonio Cámara, Lorena Cussó, Manuel Desco, Christopher Heeschen, Francisca Mulero, Xosé R. Bustelo, Carmen Guerra, and Mariano Barbacid Environmental Sciences Isotopic signals of summer denitrification in a northern hardwood forested catchment Sarah K. Wexler, Christine L. Goodale, Kevin J. McGuire, Scott W. Bailey, and Peter M. Groffman Evolution Acceleration of evolutionary spread by long-range dispersal  Oskar Hallatschek and Daniel S. Fisher Maximum likelihood inference of reticulate evolutionary histories Yun Yu, Jianrong Dong, Kevin J. Liu, and Luay Nakhleh Trajectory and genomic determinants of fungal-pathogen speciation and host adaptation  Xiao Hu, Guohua Xiao, Peng Zheng, Yanfang Shang, Yao Su, Xinyu Zhang, Xingzhong Liu, Shuai Zhan, Raymond J. St. Leger, and Chengshu Wang Rapid changes in the gut microbiome during human evolution Andrew H. Moeller, Yingying Li, Eitel Mpoudi Ngole, Steve Ahuka-Mundeke, Elizabeth V. Lonsdorf, Anne E. Pusey, Martine Peeters, Beatrice H. Hahn, and Howard Ochman Directed evolution of an ultrastable carbonic anhydrase for highly efficient carbon capture from flue gas Oscar Alvizo, Luan J. Nguyen, Christopher K. Savile, Jamie A. Bresson, Satish L. Lakhapatri, Earl O. P. Solis, Richard J. Fox, James M. Broering, Michael R. Benoit, Sabrina A. Zimmerman, Scott J. Novick, Jack Liang, and James J. Lalonde Genetics Circular permutation of a synthetic eukaryotic chromosome with the telomerator   Leslie A. Mitchell and Jef D. Boeke siRNAs from an X-linked satellite repeat promote X-chromosome recognition in Drosophila melanogaster  Debashish U. Menon, Cristian Coarfa, Weimin Xiao, Preethi H. Gunaratne, and Victoria H. Meller Rapid diversification of five Oryza AA genomes associated with rice adaptation  Qun-Jie Zhang, Ting Zhu, En-Hua Xia, Chao Shi, Yun-Long Liu, Yun Zhang, Yuan Liu, Wen-Kai Jiang, You-Jie Zhao, Shu-Yan Mao, Li-Ping Zhang, Hui Huang, Jun-Ying Jiao, Ping-Zhen Xu, Qiu-Yang Yao, Fan-Chun Zeng, Li-Li Yang, Ju Gao, Da-Yun Tao, Yue-Ju Wang, Jeffrey L. Bennetzen, and Li-Zhi Gao Completion of DNA replication in Escherichia coli Brian M. Wendel, Charmain T. Courcelle, and Justin Courcelle Immunology and Inflammation Signaling pathways activated by a protease allergen in basophils Rachel K. Rosenstein, Jelena S. Bezbradica, Shuang Yu, and Ruslan Medzhitov EGR2 is critical for peripheral naïve T-cell differentiation and the T-cell response to influenza Ning Du, Hyokjoon Kwon, Peng Li, Erin E. West, Jangsuk Oh, Wei Liao, Zuxi Yu, Min Ren, and Warren J. Leonard Stable expression and function of the inositol 1,4,5-triphosphate receptor requires palmitoylation by a DHHC6/selenoprotein K complex Gregory J. Fredericks, FuKun W. Hoffmann, Aaron H. Rose, Hanna J. Osterheld, Franz M. Hess, Frederic Mercier, and Peter R. Hoffmann Interleukin 10 modulation of pathogenic Th17 cells during fatal alphavirus encephalomyelitis Kirsten A. Kulcsar, Victoria K. Baxter, Ivorlyne P. Greene, and Diane E. Griffin Single-cell mass cytometry of TCR signaling: Amplification of small initial differences results in low ERK activation in NOD mice Michael Mingueneau, Smita Krishnaswamy, Matthew H. Spitzer, Sean C. Bendall, Erica L. Stone, Stephen M. Hedrick, Dana Pe'er, Diane Mathis, Garry P. Nolan, and Christophe Benoist Medical Sciences Forward genetic screens in mice uncover mediators and suppressors of metastatic reactivation Hua Gao, Goutam Chakraborty, Ai Ping Lee-Lim, Konstantinos J. Mavrakis, Hans-Guido Wendel, and Filippo G. Giancotti Osteoblast regulation via ligand-activated nuclear trafficking of the oxytocin receptor Adriana Di Benedetto, Li Sun, Carlo G. Zambonin, Roberto Tamma, Beatrice Nico, Cosima D. Calvano, Graziana Colaianni, Yaoting Ji, Giorgio Mori, Maria Grano, Ping Lu, Silvia Colucci, Tony Yuen, Maria I. New, Alberta Zallone, and Mone Zaidi Maresin 1 biosynthesis during platelet–neutrophil interactions is organ-protective Raja-Elie E. Abdulnour, Jesmond Dalli, Jennifer K. Colby, Nandini Krishnamoorthy, Jack Y. Timmons, Sook Hwa Tan, Romain A. Colas, Nicos A. Petasis, Charles N. Serhan, and Bruce D. Levy Cerebral small vessel disease-related protease HtrA1 processes latent TGF-β binding protein 1 and facilitates TGF-β signaling Nathalie Beaufort, Eva Scharrer, Elisabeth Kremmer, Vanda Lux, Michael Ehrmann, Robert Huber, Henry Houlden, David Werring, Christof Haffner, and Martin Dichgans Sex disparity in colonic adenomagenesis involves promotion by male hormones, not protection by female hormones  James M. Amos-Landgraf, Jarom Heijmans, Mattheus C. B. Wielenga, Elisa Dunkin, Kathy J. Krentz, Linda Clipson, Antwan G. Ederveen, Patrick G. Groothuis, Sietse Mosselman, Vanesa Muncan, Daniel W. Hommes, Alexandra Shedlovsky, William F. Dove, and Gijs R. van den Brink Genetic activation of pyruvate dehydrogenase alters oxidative substrate selection to induce skeletal muscle insulin resistance  Yasmeen Rahimi, João-Paulo G. Camporez, Max C. Petersen, Dominik Pesta, Rachel J. Perry, Michael J. Jurczak, Gary W. Cline, and Gerald I. Shulman Excess cholesterol induces mouse egg activation and may cause female infertility Ayce Yesilaltay, Gregoriy A. Dokshin, Dolores Busso, Li Wang, Dalia Galiani, Tony Chavarria, Eliza Vasile, Linda Quilaqueo, Juan Andrés Orellana, Dalia Walzer, Ruth Shalgi, Nava Dekel, David F. Albertini, Attilio Rigotti, David C. Page, and Monty Krieger Simple battery armor to protect against gastrointestinal injury from accidental ingestion Bryan Laulicht, Giovanni Traverso, Vikram Deshpande, Robert Langer, and Jeffrey M. Karp BID mediates selective killing of APC-deficient cells in intestinal tumor suppression by nonsteroidal antiinflammatory drugs Brian Leibowitz, Wei Qiu, Monica E. Buchanan, Fangdong Zou, Philip Vernon, Mary P. Moyer, Xiao-Ming Yin, Robert E. Schoen, Jian Yu, and Lin Zhang Bap1 is essential for kidney function and cooperates with Vhl in renal tumorigenesis  Shan-Shan Wang, Yi-Feng Gu, Nicholas Wolff, Karoliina Stefanius, Alana Christie, Anwesha Dey, Robert E. Hammer, Xian-Jin Xie, Dinesh Rakheja, Ivan Pedrosa, Thomas Carroll, Renée M. McKay, Payal Kapur, and James Brugarolas Microbiology Cells infected with herpes simplex virus 1 export to uninfected cells exosomes containing STING, viral mRNAs, and microRNAs Maria Kalamvoki, Te Du, and Bernard Roizman Metabolic sensor governing bacterial virulence in Staphylococcus aureus Yue Ding, Xing Liu, Feifei Chen, Hongxia Di, Bin Xu, Lu Zhou, Xin Deng, Min Wu, Cai-Guang Yang, and Lefu Lan Single gene insertion drives bioalcohol production by a thermophilic archaeon Mirko Basen, Gerrit J. Schut, Diep M. Nguyen, Gina L. Lipscomb, Robert A. Benn, Cameron J. Prybol, Brian J. Vaccaro, Farris L. Poole II, Robert M. Kelly, and Michael W. W. Adams Neuroscience SUMOylation at K340 inhibits tau degradation through deregulating its phosphorylation and ubiquitination Hong-Bin Luo, Yi-Yuan Xia, Xi-Ji Shu, Zan-Chao Liu, Ye Feng, Xing-Hua Liu, Guang Yu, Gang Yin, Yan-Si Xiong, Kuan Zeng, Jun Jiang, Keqiang Ye, Xiao-Chuan Wang, and Jian-Zhi Wang Spatial embedding of structural similarity in the cerebral cortex H. Francis Song, Henry Kennedy, and Xiao-Jing Wang Decreased segregation of brain systems across the healthy adult lifespan  Micaela Y. Chan, Denise C. Park, Neil K. Savalia, Steven E. Petersen, and Gagan S. Wig Cannabinoid CB2 receptors modulate midbrain dopamine neuronal activity and dopamine-related behavior in mice  Hai-Ying Zhang, Ming Gao, Qing-Rong Liu, Guo-Hua Bi, Xia Li, Hong-Ju Yang, Eliot L. Gardner, Jie Wu, and Zheng-Xiong Xi Anatomical accuracy of brain connections derived from diffusion MRI tractography is inherently limited Cibu Thomas, Frank Q. Ye, M. Okan Irfanoglu, Pooja Modi, Kadharbatcha S. Saleem, David A. Leopold, and Carlo Pierpaoli Ventromedial prefrontal cortex supports affective future simulation by integrating distributed knowledge Roland G. Benoit, Karl K. Szpunar, and Daniel L. Schacter The MuSK activator agrin has a separate role essential for postnatal maintenance of neuromuscular synapses Tohru Tezuka, Akane Inoue, Taisuke Hoshi, Scott D. Weatherbee, Robert W. Burgess, Ryo Ueta, and Yuji Yamanashi Asymmetrical integration of sensory information during mating decisions in grasshoppers Jan Clemens, Stefanie Krämer, and Bernhard Ronacher RHGF-1/PDZ-RhoGEF and retrograde DLK-1 signaling drive neuronal remodeling on microtubule disassembly Chun-Hao Chen, Albert Lee, Chien-Po Liao, Ya-Wen Liu, and Chun-Liang Pan Pharmacology Basal and β-adrenergic regulation of the cardiac calcium channel CaV1.2 requires phosphorylation of serine 1700 Ying Fu, Ruth E. Westenbroek, Todd Scheuer, and William A. Catterall Physiology Decreased polycystin 2 expression alters calcium-contraction coupling and changes β-adrenergic signaling pathways Ivana Y. Kuo, Andrea T. Kwaczala, Lily Nguyen, Kerry S. Russell, Stuart G. Campbell, and Barbara E. Ehrlich Plant Biology Nep1-like proteins from three kingdoms of life act as a microbe-associated molecular pattern in Arabidopsis Stan Oome, Tom M. Raaymakers, Adriana Cabral, Simon Samwel, Hannah Böhm, Isabell Albert, Thorsten Nürnberger, and Guido Van den Ackerveken Psychological and Cognitive Sciences Overtone-based pitch selection in hermit thrush song: Unexpected convergence with scale construction in human music  Emily L. Doolittle, Bruno Gingras, Dominik M. Endres, and W. Tecumseh Fitch Sustainability Science New pasture plants intensify invasive species risk Don A. Driscoll, Jane A. Catford, Jacob N. Barney, Philip E. Hulme, Inderjit, Tara G. Martin, Aníbal Pauchard, Petr Pyšek, David M. Richardson, Sophie Riley, and Vernon Visser Recent climate and air pollution impacts on Indian agriculture  Jennifer Burney and V. Ramanathan Systems Biology Isotopically nonstationary 13C flux analysis of changes in Arabidopsis thaliana leaf metabolism due to high light acclimation  Fangfang Ma, Lara J. Jazmin, Jamey D. Young, and Doug K. Allen Correction Correction for Vestergaard et al., Critical roles of isoleucine-364 and adjacent residues in a hydrophobic gate control of phospholipid transport by the mammalian P4-ATPase ATP8A2 Epigenetic Changes in the Developing Brain: Effects on Behavior Sackler Colloquium Biological Sciences — Cell Biology Chromatin landscape and circadian dynamics: Spatial and temporal organization of clock transcription Lorena Aguilar-Arnal and Paolo Sassone-Corsi Biological Sciences — Developmental Biology Notes on the role of dynamic DNA methylation in mammalian development Timothy H. Bestor, John R. Edwards, and Mathieu Boulard Biological Sciences — Genetics Angelman syndrome imprinting center encodes a transcriptional promoter Michael W. Lewis, Jason O. Brant, Joseph M. Kramer, James I. Moss, Thomas P. Yang, Peter Hansen, R. Stan Williams, and James L. Resnick Epigenetic changes in the developing brain: Effects on behavior Sackler Colloquium Biological Sciences — Developmental Biology Tissue-specific regulation and function of Grb10 during growth and neuronal commitment Robert N. Plasschaert and Marisa S. Bartolomei Open Access From the Cover Inaugural Article Classic Cozzarelli Prize Winner Front Matter This message was sent to pascal.alter@gmail.com. (....) * 425 Broadway St * Redwood City, CA 94063 * U.S.A. Copyright © 2014 by the National Academy of Sciences