Fwd: PNAS Table of Contents for 17 February 2015; Vol. 112, No. 7

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Proceedings of the National Academy of Sciences 17 February 2015; Vol. 112, No. 7 This Week in PNAS In This Issue PNAS 100th Anniversary Article Perspective Ergodic theorem, ergodic theory, and statistical mechanics Calvin C. Moore Letters (Online Only) Mandibular evidence supports Homo floresiensis as a distinct species Michael Carrington Westaway, Arthur C. Durband, Colin P. Groves, and Mark Collard Reply to Westaway et al.: Mandibular misrepresentations fail to support the invalid species Homo floresiensis Robert B. Eckhardt, Maciej Henneberg, Sakdapong Chavanaves, Alexander S. Weller, and Kenneth J. Hsü Opinion Opinion: Addressing systemic problems in the biomedical research enterprise  Bruce Alberts, Marc W. Kirschner, Shirley Tilghman, and Harold Varmus Leading scientists discuss current issues. Core Concepts Core Concept: Ergodic theory plays a key role in multiple fields  Steven Ashley A brief introduction to emerging topics in science. Retrospective Melford E. Spiro, 1920–2014 Roy G. D'Andrade Profile Profile of Alberto Kornblihtt Jennifer Viegas Commentaries Reassessment of global gene–language coevolution Keith Hunley Chemical proteomics reveals a second family of cyclic-di-AMP hydrolases John D. Helmann Interchangeable allies: Exploiting development and selection to swap symbionts Nicole M. Gerardo PNAS Plus Significance Statements PNAS Plus Significance Statements Brief statements written by the authors about the significance of their papers. Physical Sciences Applied Physical Sciences Suppression of phase separation and giant enhancement of superconducting transition temperature in FeSe1−xTex thin films Yoshinori Imai, Yuichi Sawada, Fuyuki Nabeshima, and Atsutaka Maeda The spontaneous emergence of conventions: An experimental study of cultural evolution Damon Centola and Andrea Baronchelli Chemistry Elucidation of synaptonemal complex organization by super-resolution imaging with isotropic resolution  Katharina Schücker, Thorge Holm, Christian Franke, Markus Sauer, and Ricardo Benavente Earth, Atmospheric, and Planetary Sciences Methane emissions from natural gas infrastructure and use in the urban region of Boston, Massachusetts   Kathryn McKain, Adrian Down, Steve M. Raciti, John Budney, Lucy R. Hutyra, Cody Floerchinger, Scott C. Herndon, Thomas Nehrkorn, Mark S. Zahniser, Robert B. Jackson, Nathan Phillips, and Steven C. Wofsy Droplet fragmentation: 3D imaging of a previously unidentified pore-scale process during multiphase flow in porous media Tannaz Pak, Ian B. Butler, Sebastian Geiger, Marinus I. J. van Dijke, and Ken S. Sorbie Sulfur-cycling fossil bacteria from the 1.8-Ga Duck Creek Formation provide promising evidence of evolution's null hypothesis J. William Schopf, Anatoliy B. Kudryavtsev, Malcolm R. Walter, Martin J. Van Kranendonk, Kenneth H. Williford, Reinhard Kozdon, John W. Valley, Victor A. Gallardo, Carola Espinoza, and David T. Flannery Engineering Highly multiplexed profiling of single-cell effector functions reveals deep functional heterogeneity in response to pathogenic ligands Yao Lu, Qiong Xue, Markus R. Eisele, Endah S. Sulistijo, Kara Brower, Lin Han, El-ad David Amir, Dana Pe'er, Kathryn Miller-Jensen, and Rong Fan Dynamic phototuning of 3D hydrogel stiffness Ryan S. Stowers, Shane C. Allen, and Laura J. Suggs Gold–silica quantum rattles for multimodal imaging and therapy Mathew Hembury, Ciro Chiappini, Sergio Bertazzo, Tammy L. Kalber, Glenna L. Drisko, Olumide Ogunlade, Simon Walker-Samuel, Katla Sai Krishna, Coline Jumeaux, Paul Beard, Challa S. S. R. Kumar, Alexandra E. Porter, Mark F. Lythgoe, Cédric Boissière, Clément Sanchez, and Molly M. Stevens Physics Scaling laws describe memories of host–pathogen riposte in the HIV population John P. Barton, Mehran Kardar, and Arup K. Chakraborty Magnetic nanopantograph in the SrCu2(BO3)2 Shastry–Sutherland lattice Guillaume Radtke, Andrés Saúl, Hanna A. Dabkowska, Myron B. Salamon, and Marcelo Jaime Sustainability Science Rapid loss of lakes on the Mongolian Plateau Shengli Tao, Jingyun Fang, Xia Zhao, Shuqing Zhao, Haihua Shen, Huifeng Hu, Zhiyao Tang, Zhiheng Wang, and Qinghua Guo Social Sciences Psychological and Cognitive Sciences Self-affirmation alters the brain's response to health messages and subsequent behavior change Emily B. Falk, Matthew Brook O'Donnell, Christopher N. Cascio, Francis Tinney, Yoona Kang, Matthew D. Lieberman, Shelley E. Taylor, Lawrence An, Kenneth Resnicow, and Victor J. Strecher Role of the motor system in language knowledge Iris Berent, Anna-Katharine Brem, Xu Zhao, Erica Seligson, Hong Pan, Jane Epstein, Emily Stern, Albert M. Galaburda, and Alvaro Pascual-Leone Social Sciences The spontaneous emergence of conventions: An experimental study of cultural evolution Damon Centola and Andrea Baronchelli Sustainability Science Methane emissions from natural gas infrastructure and use in the urban region of Boston, Massachusetts   Kathryn McKain, Adrian Down, Steve M. Raciti, John Budney, Lucy R. Hutyra, Cody Floerchinger, Scott C. Herndon, Thomas Nehrkorn, Mark S. Zahniser, Robert B. Jackson, Nathan Phillips, and Steven C. Wofsy Biological Sciences Applied Biological Sciences Dynamic phototuning of 3D hydrogel stiffness Ryan S. Stowers, Shane C. Allen, and Laura J. Suggs Tunable control of antibody immobilization using electric field Sam Emaminejad, Mehdi Javanmard, Chaitanya Gupta, Shuai Chang, Ronald W. Davis, and Roger T. Howe Glycosylation profiles determine extravasation and disease-targeting properties of armed antibodies Dario Venetz, Christian Hess, Chia-wei Lin, Markus Aebi, and Dario Neri Biochemistry Mitochondrial peroxiredoxin functions as crucial chaperone reservoir in Leishmania infantum Filipa Teixeira, Helena Castro, Tânia Cruz, Eric Tse, Philipp Koldewey, Daniel R. Southworth, Ana M. Tomás, and Ursula Jakob Distinct activation of an E2 ubiquitin-conjugating enzyme by its cognate E3 ligases Itamar Cohen, Reuven Wiener, Yuval Reiss, and Tommer Ravid Archaeal replicative primases can perform translesion DNA synthesis  Stanislaw K. Jozwiakowski, Farimah Borazjani Gholami, and Aidan J. Doherty A conserved amphipathic helix is required for membrane tubule formation by Yop1p  Jacob P. Brady, Jolyon K. Claridge, Peter G. Smith, and Jason R. Schnell Structural basis for transcription reactivation by RapA Bin Liu, Yuhong Zuo, and Thomas A. Steitz Inhibition of the β-barrel assembly machine by a peptide that binds BamD Christine L. Hagan, Joseph S. Wzorek, and Daniel Kahne Distinct pathways of RNA polymerase regulation by a phage-encoded factor Daria Esyunina, Evgeny Klimuk, Konstantin Severinov, and Andrey Kulbachinskiy A CaMKII/PDE4D negative feedback regulates cAMP signaling Delphine Mika, Wito Richter, and Marco Conti Biophysics and Computational Biology CryoEM and mutagenesis reveal that the smallest capsid protein cements and stabilizes Kaposi's sarcoma-associated herpesvirus capsid Xinghong Dai, Danyang Gong, Yuchen Xiao, Ting-Ting Wu, Ren Sun, and Z. Hong Zhou Scaling laws describe memories of host–pathogen riposte in the HIV population John P. Barton, Mehran Kardar, and Arup K. Chakraborty Elucidation of synaptonemal complex organization by super-resolution imaging with isotropic resolution  Katharina Schücker, Thorge Holm, Christian Franke, Markus Sauer, and Ricardo Benavente Residue-level resolution of alphavirus envelope protein interactions in pH-dependent fusion Xiancheng Zeng, Suchetana Mukhopadhyay, and Charles L. Brooks III Proton-coupled electron transfer and the role of water molecules in proton pumping by cytochrome c oxidase Vivek Sharma, Giray Enkavi, Ilpo Vattulainen, Tomasz Róg, and Mårten Wikström Single liposome analysis of peptide translocation by the ABC transporter TAPL Tina Zollmann, Gemma Moiset, Franz Tumulka, Robert Tampé, Bert Poolman, and Rupert Abele Absence of knots in known RNA structures Cristian Micheletti, Marco Di Stefano, and Henri Orland Phylogenomics with paralogs Marc Hellmuth, Nicolas Wieseke, Marcus Lechner, Hans-Peter Lenhof, Martin Middendorf, and Peter F. Stadler Molecular mechanisms underlying the effect of the novel BK channel opener GoSlo: Involvement of the S4/S5 linker and the S6 segment Timothy I. Webb, Aravind Singh Kshatri, Roddy J. Large, Adebola Morayo Akande, Subhrangsu Roy, Gerard P. Sergeant, Noel G. McHale, Keith D. Thornbury, and Mark A. Hollywood Cell Biology Autoinhibition and relief mechanism for Polo-like kinase 4 Joseph E. Klebba, Daniel W. Buster, Tiffany A. McLamarrah, Nasser M. Rusan, and Gregory C. Rogers Aged insulin granules display reduced microtubule-dependent mobility and are disposed within actin-positive multigranular bodies  Peter Hoboth, Andreas Müller, Anna Ivanova, Hassan Mziaut, Jaber Dehghany, Anke Sönmez, Martina Lachnit, Michael Meyer-Hermann, Yannis Kalaidzidis, and Michele Solimena Genome-wide targeting of the epigenetic regulatory protein CTCF to gene promoters by the transcription factor TFII-I  Rodrigo Peña-Hernández, Maud Marques, Khalid Hilmi, Teijun Zhao, Amine Saad, Moulay A. Alaoui-Jamali, Sonia V. del Rincon, Todd Ashworth, Ananda L. Roy, Beverly M. Emerson, and Michael Witcher The autophagic machinery ensures nonlytic transmission of mycobacteria Lilli Gerstenmaier, Rachel Pilla, Lydia Herrmann, Hendrik Herrmann, Monica Prado, Geno J. Villafano, Margot Kolonko, Rudolph Reimer, Thierry Soldati, Jason S. King, and Monica Hagedorn Developmental Biology Analysis of gene–environment interactions in postnatal development of the mammalian intestine  Seth Rakoff-Nahoum, Yong Kong, Steven H. Kleinstein, Sathish Subramanian, Philip P. Ahern, Jeffrey I. Gordon, and Ruslan Medzhitov Adipogenesis and epicardial adipose tissue: A novel fate of the epicardium induced by mesenchymal transformation and PPARγ activation Yukiko Yamaguchi, Susana Cavallero, Michaela Patterson, Hua Shen, Jian Xu, S. Ram Kumar, and Henry M. Sucov Ecology DNA barcoding and metabarcoding of standardized samples reveal patterns of marine benthic diversity  Matthieu Leray and Nancy Knowlton Environmental Sciences Breakdown of coral colonial form under reduced pH conditions is initiated in polyps and mediated through apoptosis Hagit Kvitt, Esti Kramarsky-Winter, Keren Maor-Landaw, Keren Zandbank, Ariel Kushmaro, Hanna Rosenfeld, Maoz Fine, and Dan Tchernov Evolution Bacterial proteins pinpoint a single eukaryotic root Romain Derelle, Guifré Torruella, Vladimír Klimeš, Henner Brinkmann, Eunsoo Kim, Čestmír Vlček, B. Franz Lang, and Marek Eliáš Sulfur-cycling fossil bacteria from the 1.8-Ga Duck Creek Formation provide promising evidence of evolution's null hypothesis J. William Schopf, Anatoliy B. Kudryavtsev, Malcolm R. Walter, Martin J. Van Kranendonk, Kenneth H. Williford, Reinhard Kozdon, John W. Valley, Victor A. Gallardo, Carola Espinoza, and David T. Flannery Experimental replacement of an obligate insect symbiont  Nancy A. Moran and Yueli Yun Rate of language evolution is affected by population size Lindell Bromham, Xia Hua, Thomas G. Fitzpatrick, and Simon J. Greenhill Dynamics of gene circuits shapes evolvability  Alba Jiménez, Andreea Munteanu, and James Sharpe Crossovers are associated with mutation and biased gene conversion at recombination hotspots  Barbara Arbeithuber, Andrea J. Betancourt, Thomas Ebner, and Irene Tiemann-Boege Matching times of leading and following suggest cooperation through direct reciprocity during V-formation flight in ibis  Bernhard Voelkl, Steven J. Portugal, Markus Unsöld, James R. Usherwood, Alan M. Wilson, and Johannes Fritz Genetics NADPH oxidase 4 is a critical mediator in Ataxia telangiectasia disease  Urbain Weyemi, Christophe E. Redon, Towqir Aziz, Rohini Choudhuri, Daisuke Maeda, Palak R. Parekh, Michael Y. Bonner, Jack L. Arbiser, and William M. Bonner Haploinsufficiency screen highlights two distinct groups of ribosomal protein genes essential for embryonic stem cell fate  Simon Fortier, Tara MacRae, Mélanie Bilodeau, Tobias Sargeant, and Guy Sauvageau Double-stranded RNA made in C. elegans neurons can enter the germline and cause transgenerational gene silencing Sindhuja Devanapally, Snusha Ravikumar, and Antony M. Jose Immunology and Inflammation PTEN regulates natural killer cell trafficking in vivo Jeffrey W. Leong, Stephanie E. Schneider, Ryan P. Sullivan, Bijal A. Parikh, Bryan A. Anthony, Anvita Singh, Brea A. Jewell, Timothy Schappe, Julia A. Wagner, Daniel C. Link, Wayne M. Yokoyama, and Todd A. Fehniger Suppression of systemic autoimmunity by the innate immune adaptor STING Shruti Sharma, Allison M. Campbell, Jennie Chan, Stefan A. Schattgen, Gregory M. Orlowski, Ribhu Nayar, Annie H. Huyler, Kerstin Nündel, Chandra Mohan, Leslie J. Berg, Mark J. Shlomchik, Ann Marshak-Rothstein, and Katherine A. Fitzgerald The SWI/SNF chromatin remodeling complex regulates germinal center formation by repressing Blimp-1 expression Jinwook Choi, Shin Jeon, Seungjin Choi, Kyungsoo Park, and Rho Hyun Seong Overlapping hotspots in CDRs are critical sites for V region diversification  Lirong Wei, Richard Chahwan, Shanzhi Wang, Xiaohua Wang, Phuong T. Pham, Myron F. Goodman, Aviv Bergman, Matthew D. Scharff, and Thomas MacCarthy Noninvasive mapping of pancreatic inflammation in recent-onset type-1 diabetes patients Jason L. Gaglia, Mukesh Harisinghani, Iman Aganj, Gregory R. Wojtkiewicz, Sandeep Hedgire, Christophe Benoist, Diane Mathis, and Ralph Weissleder Macrophages eat cancer cells using their own calreticulin as a guide: Roles of TLR and Btk  Mingye Feng, James Y. Chen, Rachel Weissman-Tsukamoto, Jens-Peter Volkmer, Po Yi Ho, Kelly M. McKenna, Samuel Cheshier, Michael Zhang, Nan Guo, Phung Gip, Siddhartha S. Mitra, and Irving L. Weissman Physical detection of influenza A epitopes identifies a stealth subset on human lung epithelium evading natural CD8 immunity Derin B. Keskin, Bruce B. Reinhold, Guang Lan Zhang, Alexander R. Ivanov, Barry L. Karger, and Ellis L. Reinherz Aberrant recombination and repair during immunoglobulin class switching in BRCA1-deficient human B cells  Andrea Björkman, Per Qvist, Likun Du, Margarita Bartish, Apostolos Zaravinos, Konstantinos Georgiou, Anders D. Børglum, Richard A. Gatti, Therese Törngren, and Qiang Pan-Hammarström IL-4 abrogates TH17 cell-mediated inflammation by selective silencing of IL-23 in antigen-presenting cells  Emmanuella Guenova, Yuliya Skabytska, Wolfram Hoetzenecker, Günther Weindl, Karin Sauer, Manuela Tham, Kyu-Won Kim, Ji-Hyeon Park, Ji Hae Seo, Desislava Ignatova, Antonio Cozzio, Mitchell P. Levesque, Thomas Volz, Martin Köberle, Susanne Kaesler, Peter Thomas, Reinhard Mailhammer, Kamran Ghoreschi, Knut Schäkel, Boyko Amarov, Martin Eichner, Martin Schaller, Rachael A. Clark, Martin Röcken, and Tilo Biedermann Medical Sciences Adverse childhood experiences and physiological wear-and-tear in midlife: Findings from the 1958 British birth cohort Cristina Barboza Solís, Michelle Kelly-Irving, Romain Fantin, Muriel Darnaudéry, Jérôme Torrisani, Thierry Lang, and Cyrille Delpierre Gold–silica quantum rattles for multimodal imaging and therapy Mathew Hembury, Ciro Chiappini, Sergio Bertazzo, Tammy L. Kalber, Glenna L. Drisko, Olumide Ogunlade, Simon Walker-Samuel, Katla Sai Krishna, Coline Jumeaux, Paul Beard, Challa S. S. R. Kumar, Alexandra E. Porter, Mark F. Lythgoe, Cédric Boissière, Clément Sanchez, and Molly M. Stevens TCL1 targeting miR-3676 is codeleted with tumor protein p53 in chronic lymphocytic leukemia Veronica Balatti, Lara Rizzotto, Cecelia Miller, Alexey Palamarchuk, Paolo Fadda, Rosantony Pandolfo, Laura Z. Rassenti, Erin Hertlein, Amy S. Ruppert, Arletta Lozanski, Gerard Lozanski, Thomas J. Kipps, John C. Byrd, Carlo M. Croce, and Yuri Pekarsky Microbiology An HD-domain phosphodiesterase mediates cooperative hydrolysis of c-di-AMP to affect bacterial growth and virulence TuAnh Ngoc Huynh, Shukun Luo, Daniel Pensinger, John-Demian Sauer, Liang Tong, and Joshua J. Woodward Novel mixed-linkage β-glucan activated by c-di-GMP in Sinorhizobium meliloti Daniel Pérez-Mendoza, Miguel Ángel Rodríguez-Carvajal, Lorena Romero-Jiménez, Gabriela de Araujo Farias, Javier Lloret, María Trinidad Gallegos, and Juan Sanjuán Differential RNA-seq of Vibrio cholerae identifies the VqmR small RNA as a regulator of biofilm formation Kai Papenfort, Konrad U. Förstner, Jian-Ping Cong, Cynthia M. Sharma, and Bonnie L. Bassler Age-related immune clearance of hepatitis B virus infection requires the establishment of gut microbiota Han-Hsuan Chou, Wei-Hung Chien, Li-Ling Wu, Chi-Hung Cheng, Chen-Han Chung, Jau-Haw Horng, Yen-Hsuan Ni, Hong-Tai Tseng, Dafei Wu, Xuemei Lu, Hurng-Yi Wang, Pei-Jer Chen, and Ding-Shinn Chen Generation of reactive oxygen species by lethal attacks from competing microbes Tao G. Dong, Shiqi Dong, Christy Catalano, Richard Moore, Xiaoye Liang, and John J. Mekalanos Quorum sensing and policing of Pseudomonas aeruginosa social cheaters Meizhen Wang, Amy L. Schaefer, Ajai A. Dandekar, and E. Peter Greenberg Characterization of nonprimate hepacivirus and construction of a functional molecular clone Troels K. H. Scheel, Amit Kapoor, Eiko Nishiuchi, Kenny V. Brock, Yingpu Yu, Linda Andrus, Meigang Gu, Randall W. Renshaw, Edward J. Dubovi, Sean P. McDonough, Gerlinde R. Van de Walle, W. Ian Lipkin, Thomas J. Divers, Bud C. Tennant, and Charles M. Rice Cross-talk and regulatory interactions between the essential response regulator RpaB and cyanobacterial circadian clock output Javier Espinosa, Joseph S. Boyd, Raquel Cantos, Paloma Salinas, Susan S. Golden, and Asuncion Contreras An intermolecular electrostatic interaction controls the prepore-to-pore transition in a cholesterol-dependent cytolysin Kristin R. Wade, Eileen M. Hotze, Michael J. Kuiper, Craig J. Morton, Michael W. Parker, and Rodney K. Tweten Noncanonical coproporphyrin-dependent bacterial heme biosynthesis pathway that does not use protoporphyrin Harry A. Dailey, Svetlana Gerdes, Tamara A. Dailey, Joseph S. Burch, and John D. Phillips TCF1 and LEF1 act as T-cell intrinsic HTLV-1 antagonists by targeting Tax Guangyong Ma, Jun-ichirou Yasunaga, Hirofumi Akari, and Masao Matsuoka N2 gas is an effective fertilizer for bioethanol production by Zymomonas mobilis Timothy A. Kremer, Breah LaSarre, Amanda L. Posto, and James B. McKinlay Revealing the density of encoded functions in a viral RNA  Nikesh Patel, Eric C. Dykeman, Robert H. A. Coutts, George P. Lomonossoff, David J. Rowlands, Simon E. V. Phillips, Neil Ranson, Reidun Twarock, Roman Tuma, and Peter G. Stockley Neuroscience Two-photon brightness of azobenzene photoswitches designed for glutamate receptor optogenetics Elizabeth C. Carroll, Shai Berlin, Joshua Levitz, Michael A. Kienzler, Zhe Yuan, Dorte Madsen, Delmar S. Larsen, and Ehud Y. Isacoff Self-affirmation alters the brain's response to health messages and subsequent behavior change Emily B. Falk, Matthew Brook O'Donnell, Christopher N. Cascio, Francis Tinney, Yoona Kang, Matthew D. Lieberman, Shelley E. Taylor, Lawrence An, Kenneth Resnicow, and Victor J. Strecher Behavioral training reverses global cortical network dysfunction induced by perinatal antidepressant exposure Xiaoming Zhou, Jordan Y.-F. Lu, Ryan D. Darling, Kimberly L. Simpson, Xiaoqing Zhu, Fang Wang, Liping Yu, Xinde Sun, Michael M. Merzenich, and Rick C. S. Lin Rescue of homeostatic regulation of striatal excitability and locomotor activity in a mouse model of Huntington's disease  Yumei Cao, David Bartolomé-Martín, Naama Rotem, Carlos Rozas, Shlomo S. Dellal, Marcelo A. Chacon, Bashkim Kadriu, Maria Gulinello, Kamran Khodakhah, and Donald S. Faber CRYPTOCHROME-mediated phototransduction by modulation of the potassium ion channel β-subunit redox sensor  Keri J. Fogle, Lisa S. Baik, Jerry H. Houl, Tri T. Tran, Logan Roberts, Nicole A. Dahm, Yu Cao, Ming Zhou, and Todd C. Holmes Plasma butyrylcholinesterase regulates ghrelin to control aggression  Vicky Ping Chen, Yang Gao, Liyi Geng, Robin J. Parks, Yuan-Ping Pang, and Stephen Brimijoin Network-based metaanalysis identifies HNF4A and PTBP1 as longitudinally dynamic biomarkers for Parkinson's disease Jose A. Santiago and Judith A. Potashkin Pharmacology Regulator of G protein signaling 6 is a critical mediator of both reward-related behavioral and pathological responses to alcohol Adele Stewart, Biswanath Maity, Simon P. Anderegg, Chantal Allamargot, Jianqi Yang, and Rory A. Fisher Physiology Potassium channelopathy-like defect underlies early-stage cerebrovascular dysfunction in a genetic model of small vessel disease Fabrice Dabertrand, Christel Krøigaard, Adrian D. Bonev, Emmanuel Cognat, Thomas Dalsgaard, Valérie Domenga-Denier, David C. Hill-Eubanks, Joseph E. Brayden, Anne Joutel, and Mark T. Nelson A fluid secretion pathway unmasked by acinar-specific Tmem16A gene ablation in the adult mouse salivary gland Marcelo A. Catalán, Yusuke Kondo, Gaspar Peña-Munzenmayer, Yasna Jaramillo, Frances Liu, Sooji Choi, Edward Crandall, Zea Borok, Per Flodby, Gary E. Shull, and James E. Melvin Plant Biology An early secretory pathway mediated by GNOM-LIKE 1 and GNOM is essential for basal polarity establishment in Arabidopsis thaliana  Siamsa M. Doyle, Ash Haeger, Thomas Vain, Adeline Rigal, Corrado Viotti, Małgorzata Łangowska, Qian Ma, Jiří Friml, Natasha V. Raikhel, Glenn R. Hicks, and Stéphanie Robert A methyltransferase required for proper timing of the vernalization response in Arabidopsis Joohyun Lee, Jae-Young Yun, Wei Zhao, Wen-Hui Shen, and Richard M. Amasino Auxin binding protein 1 (ABP1) is not required for either auxin signaling or Arabidopsis development Yangbin Gao, Yi Zhang, Da Zhang, Xinhua Dai, Mark Estelle, and Yunde Zhao Psychological and Cognitive Sciences Role of the motor system in language knowledge Iris Berent, Anna-Katharine Brem, Xu Zhao, Erica Seligson, Hong Pan, Jane Epstein, Emily Stern, Albert M. Galaburda, and Alvaro Pascual-Leone Sustainability Science Rapid loss of lakes on the Mongolian Plateau Shengli Tao, Jingyun Fang, Xia Zhao, Shuqing Zhao, Haihua Shen, Huifeng Hu, Zhiyao Tang, Zhiheng Wang, and Qinghua Guo Systems Biology Highly multiplexed profiling of single-cell effector functions reveals deep functional heterogeneity in response to pathogenic ligands Yao Lu, Qiong Xue, Markus R. Eisele, Endah S. Sulistijo, Kara Brower, Lin Han, El-ad David Amir, Dana Pe'er, Kathryn Miller-Jensen, and Rong Fan A strategy for tissue self-organization that is robust to cellular heterogeneity and plasticity Alec E. Cerchiari, James C. Garbe, Noel Y. Jee, Michael E. Todhunter, Kyle E. Broaders, Donna M. Peehl, Tejal A. Desai, Mark A. LaBarge, Matthew Thomson, and Zev J. Gartner Corrections (Online only) Correction for Das et al., Structure of CrgA, a cell division structural and regulatory protein from Mycobacterium tuberculosis, in lipid bilayers Correction for Liu et al., Altered ubiquitin causes perturbed calcium homeostasis, hyperactivation of calpain, dysregulated differentiation, and cataract Correction for Jeon et al., Human 3D vascularized organotypic microfluidic assays to study breast cancer cell extravasation Retraction (Online Only) Retraction for Zhang et al., Metabolic regulation of SIRT1 transcription via a HIC1:CtBP corepressor complex Open Access From the Cover Inaugural Article Classic Cozzarelli Prize Winner Front Matter This message was sent to pascal.alter@gmail.com. (....) Or by mail: Customer Service * 425 Broadway St * Redwood City, CA 94063 * U.S.A. Copyright © 2015 by the National Academy of Sciences